Discovery Life Channel

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food; only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.

After successful sleeve gastrectomy procedures, the Dreier twins collectively lose more than 400 pounds and work toward skin surgeries when a major life event disrupts their world and threatens their progress.

Unable to stand for more than a short period of time, Karina's weight places a burden on her parents and drives a wedge between her and her sister.

Kenae' is already big before her weight gain takes off after the death of her beloved mother; refusing to deal with the pain, Kenae' turns to food to fill the void.

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her three daughters; if he doesn't lose weight soon, he knows he'll lose either his girls or his life.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children; Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.

Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her three daughters; if he doesn't lose weight soon, he knows he'll lose either his girls or his life.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children; Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

A brain ailment strikes a 22-year-old woman.

Eight-year-old Joshua Wooten is rushed to the ER after his mother finds him collapsed on the bedroom floor. When it is found that Joshua is struggling to breathe and his health continues to decline, doctors are left baffled at what is the cause.

A single mother finds she can no longer walk.

A military wife suffers a sudden paralysis in her leg that defies explanation; doctors discover it may have something to do with her husband's top secret work.

When a young woman goes to the ER with severe abdominal pains, the doctors find a rare and virulent type of cancer that gives her ten years to live.

After moving to a new apartment, the mother of a little girl notices her child is suffering from a burning rash; doctors work to solve what caused it.

A swimmer gets attacks of near-paralytic exhaustion, after which his urine becomes strangely dark; when he has a heart attack, a doctor suspects something sinister.

A college student comes down with a purple rash that literally spreads before his eyes; as his health deteriorates, the doctor must race to find the cause.

A young child blisters after exposure to a few minutes of sun; Doctors make a discovery that the child's inability to sweat is one symptom of a mysterious disorder.

After a young man blows his nose, he becomes violently ill and passes out; his condition progressively worsens while doctors try to diagnose what's wrong before one more sneeze kills him.

A healthy pastor feels like he has had a heart attack every day for years; a friend gives advice and doctors try to solve the mystery.

Decades after a car accident, a woman loses the ability to speak; when her speech returns, she speaks with a foreign accent; one doctor thinks he knows why.

A mother tries to protect her children from their father's hoard; an artist chooses frog, penguins and banana peels over her boyfriend.

Maggie's piles of collections is putting her son's life at risk; Bob's passion for swimming pool parts is pushing his family to the brink.

Traci is pregnant and desperate to move back home, but it's filled floor to ceiling with her mother's stuff.

Kathleen discovers a hoard of mice living in her kitchen; spending the night in a hoard might be the end of a marriage before it even begins.

Medical responders were not able to get in Renee's front door after she had fallen unconscious in her home.

Rick tries to salvage his cluttered home that was nearly destroyed in a house fire; Linda must get her house up to code in 60 days or she will be on the streets.

Traci is pregnant and desperate to move back home, but it's filled floor to ceiling with her mother's stuff.

Kathleen discovers a hoard of mice living in her kitchen; spending the night in a hoard might be the end of a marriage before it even begins.

Medical responders were not able to get in Renee's front door after she had fallen unconscious in her home.

Rick tries to salvage his cluttered home that was nearly destroyed in a house fire; Linda must get her house up to code in 60 days or she will be on the streets.

A mother tries to protect her children from their father's hoard; an artist chooses frog, penguins and banana peels over her boyfriend.

Maggie's piles of collections is putting her son's life at risk; Bob's passion for swimming pool parts is pushing his family to the brink.

After losing 275 lbs., Mikki became a fitness fanatic, but the weight loss left her with a lot of sagging skin; Denise's obesity always made her feel invisible, but after losing 200 lbs. the skin still hinders her from fitting in with her family.

Rebecca lost her weight to be more active with her young son, but the plan backfired because she's now trapped in her excess skin; after his dad died, Sal dropped a ton of weight, but with all the excess skin, he fears he will never become a dad.

Autumn wants to make up for lost time with her son, but the excess skin from major weight loss is holding her back; Cody always pretended to be happy when he was 500-lbs, but after losing the weight, he's covered in skin and is sick of pretending.

Ronnie and Michael Robinette are thriving, but their extra skin is getting in the way; at 64, Renee's excess skin inhibits her from enjoying her relationship and expressing her true self in public.

Dr. Dow and J.J. Virgin are called in to save a pizza addict; consuming 80 times more pizza than an average American.

A woman is addicted to ice cream bars, eating up to 40 bars a day.

A 26 year old man is addicted to maple syrup.

A 34 year old woman in obsessed with eating cheesy potatoes; specialists are called in to help with this damaging and compulsive diet.

Mysti consumes as much as 40 gallons of tartar sauce a year.

A 34-year old diabetic is in need of help to save him from his addiction to cheeseburgers.

After a horrific car accident as a child, Heather's ankle was rebuilt from parts of her body; now it's up to Dr. Vincent to help her walk again.

Dr. Vincent tries to save a man's enormous toe; Dr. Schaeffer has his hands full treating a little boy with big demands; a man with incredibly long toes.

Dr. Schaeffer has to straighten a woman's serpentine foot to reset her life, as Dr. Vincent gets a drummer's foot back on the beat.

Dr. Ebonie's skills are tested as she attempts to diagnose a patient with feet covered in huge, wart-like masses; Dr. Brad is confronted with a mystery case that could be related to the elephant man as well as a patient with paper-thin skin.

Nate sees Dr. Brad for help with the raging calluses on his feet; Savannah has a rare condition that made her big toe grow to an enormous size and hopes Dr. Ebonie can help; Dr. Brad is determined to uncover the mystery behind John's foot growth.

A woman undergoes a risky craniotomy; a man searches for answers.

A teenager is rushed to the hospital after taking aspirin to help alleviate altitude sickness; a woman has pain in her arm that mysteriously spreads.

A woman and her husband decide to start a family after numerous negative pregnancy tests; a man appears to suffer an embolism.

A 3-month-old boy has breathing difficulties; a woman has stomach problems; stepping on a crochet hook causes strange problems for a patient.

An infant shows diverse symptoms; an ER nurse gets a diagnosis of lymphoma, before another symptom reveals her true illness.

Twins battle seemingly unrelated illnesses.

A woman and her husband decide to start a family after numerous negative pregnancy tests; a man appears to suffer an embolism.