Discovery Life Channel

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Living with his family, Lucas wants to spread his wings and fly, but at 600 pounds, he can't take off. All he does is eat and game, and if he wants to leave the nest and live a normal life, he needs Dr. Now's help to lose over 400 pounds.

Margaret's life at 700 pounds is in need of a jump-start; at age 35, she is a mama's girl; it's time for Margaret to get out of bed, overcome her food addiction and break away from the comfort of her mother so she can finally live her life.

Living with his family, Lucas wants to spread his wings and fly, but at 600 pounds, he can't take off. All he does is eat and game, and if he wants to leave the nest and live a normal life, he needs Dr. Now's help to lose over 400 pounds.

Margaret's life at 700 pounds is in need of a jump-start; at age 35, she is a mama's girl; it's time for Margaret to get out of bed, overcome her food addiction and break away from the comfort of her mother so she can finally live her life.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Dr. Mercy tries to remove Price's lipoma, which is so big that it has gotten in the way of his relationship; Ashley's case of neurofibromatosis is one of the worst in the country; Becca was born with a birthmark that covers the majority of her face.

Jorge's case of rhinophyma is so bad that he has a difficult time breathing; Tracy's body is covered in hundreds of lipomas; Cha comes to Dr. Mercy to help her gain her confidence back due to the bumps on her face.

Joseph's neck lipoma gets in the way of everything he does; Rachel's condition gives her a full beard that she shaves daily; Summer has seven cysts, including one she calls her unicorn horn.

Tiffany has a rare condition that has left her in so much pain, she's couch bound; Brad's face is covered in nodules from a condition that affects less than one in a million people; Lydia's life is impacted by her excessive sweating.

A woman is impaled on an iron spike; a man spears his friend on a fishing trip; an elderly gardener's shears are lodged in his eye.

A man is impaled on a fence post; a farmer has an object lodged in his brain; a woman is skewered on a hooked pole when she feeds the birds.

A woman gets a Christmas tree imbedded in her neck; a boy out fishing almost chokes on a barb; a man is filled with enough air to fill 1000 balloons; learn how they survived.

A car accident leaves a pole penetrating a man's mouth and neck, a man accidentally eats a sewing needle and a 75-year-old man finds out he has had a nail in his face.

A woman has over 50 orgasms a day, which makes sex painful; in the United States, a man is only 2 feet, eleven inches tall due to a rare condition called primordial dwarfism.

Four sisters are unable to move; conjoined twins find love; a man's chin won't stop growing; a girl can't smile.

The Pope blesses a severely disfigured Italian man; girl born without arms and thighs thrives, and a family with the world's longest hair.

A man just 16 inches tall campaigns for the record of smallest man; the elephant man gets married.

A woman with an extremely rare skin disorder looks more than twice her age; a baby undergoes risky surgery to cure a mysterious brain condition; three brothers with the same genetic disorder hope for a miracle.

After moving to a new apartment, the mother of a little girl notices her child is suffering from a burning rash; doctors work to solve what caused it.

A swimmer gets attacks of near-paralytic exhaustion, after which his urine becomes strangely dark; when he has a heart attack, a doctor suspects something sinister.

A college student comes down with a purple rash that literally spreads before his eyes; as his health deteriorates, the doctor must race to find the cause.

A young child blisters after exposure to a few minutes of sun; Doctors make a discovery that the child's inability to sweat is one symptom of a mysterious disorder.

After a young man blows his nose, he becomes violently ill and passes out; his condition progressively worsens while doctors try to diagnose what's wrong before one more sneeze kills him.

A swimmer gets attacks of near-paralytic exhaustion, after which his urine becomes strangely dark; when he has a heart attack, a doctor suspects something sinister.