Discovery Life Channel

Milagros lives with tumors so heavy that her face droops down to her torso; after hiding away, a health scare is forcing her out into the world; twenty-one-year-old Lizzie is preparing to live independently even after tumors have grown over her eyes.

Summer has macromastia, a condition that causes her breasts to keep growing; with constant pain in her back and neck from breasts that are now a third of her overall body weight, Summer travels from Scotland to Los Angeles looking for answers.

In Brazil, Claudio lives with a condition that bent his head backward; ahead of his 50th birthday, he wants to climb a sacred mountain; in Norway, Birgitte lives with a different presentation of the same condition; she's training for the next Paralympics.

Riah has been addicted to baby wipes since she was 15 and goes through 500 a day, using them instead of showering; Brea has been addicted to eating sand for the past five years.

Danielle has been addicted to vapor rub for more than 20 years, going through more than 30 jars, inhalers and patches every week; 19-year-old Allison has been eating tires for the past six years, consuming 14 pounds every month.

A 44-year-old mother of six has had at least 30 plastic surgery procedures to build the most extreme body in the world; she plans to go under the knife again to double her breast size to a shocking QQQ.

Keisha is addicted to chewing on urine-soaked diapers; 50-year-old Vladimir is obsessed with using leeches.

Winner of the Uganda's Ugliest Man contest, Godfrey has a rare disorder that has left him disfigured; with 10 children, a new baby on the way, and his condition worsening, he is seeking medical answers that will determine his future.

Kirsten must gain independence to get a full gastric bypass; Michael struggles to lose and battles anger issues; Michael's wife, Roni, wants surgery too.

Zsalynn's 360-body lift procedure proves to be more challenging than expected; lonely and depressed since her gastric surgery, Olivia wants skin removal surgery but struggles to lose the weight to qualify.

Diagnosed with cancer and battling depression, Bettie Jo finds out she's pregnant, and she must find a way to cope with the help of her husband; Susan suffers a major setback after surgery for her excess skin.

A number of challenges seem to have cornered Betti Jo and her husband; Susan encounters a serious problem that can throw everything off track.

Over 11 years, Melissa has lost 500 pounds and saw her weight drop to 137 pounds; now facing marital problems, three pregnancies, and life as a single mom, Melissa is struggling with a 150-pound weight gain and finds herself at a crossroads.

Steven Assanti weighs nearly 800 pounds and his brother Justin almost 600 pounds, and although they can't stand each other, their father packs up the family to travel across the country and seek help.

After successful sleeve gastrectomy procedures, the Dreier twins collectively lose more than 400 pounds and work toward skin surgeries when a major life event disrupts their world and threatens their progress.

Erica must return to California to continue her weight-loss journey, but she fears past emotional trauma will derail her progress.

Ashley lost over 200 lbs. in Houston, but a family of enablers threatens her progress; Diana has shed 300 lbs., but knee damage may cause her to regain weight.

Ashley hits an emotional wall and is desperate for skin surgery, but she's not losing any weight; after being evicted, Nicole is forced to move back to Ohio, which could impact her weight loss journey.

Ashley lost over 200 lbs. in Houston, but a family of enablers threatens her progress; Diana has shed 300 lbs., but knee damage may cause her to regain weight.