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When Watson runs into Gregson and his girlfriend (Virginia Madsen), a former NYPD officer, she accidentally causes problems in their relationship; a woman who willed her considerable estate to a beloved dog is murdered.

Holmes and Watson investigate the death of a wealthy businessman who a witness claims was chased down by a large, glowing animal; Sherlock believes ME Hawes' work may be compromised because of the trauma caused by the morgue bombing.

When a vigilante dressed as a comic book hero is murdered, it's up to Holmes and Watson to find the man's true identity and locate his killer; Morland tries to charm Watson into doing him a favor.

Holmes and Watson must determine whether a survival doctor is a victim of foul play or has purposely gone into hiding; Holmes behaves oddly when his relationship with Fiona reaches a crucial point.

A woman claiming to be a former associate of Sherlock's brother tells Holmes and Watson her life is in danger.

Eli and Alicia ask a well-respected civil rights lawyer (Ron Rifkin) to help stop a recount when potential voter fraud is discovered; Diane learns she unknowingly submitted false evidence in Cary's case.

Alicia's future is uncertain when she is forced to resign as State's Attorney; R.D. (Oliver Platt) hires Cary and Diane to argue against conservative lawyers in a test case involving mandatory minimum sentencing.