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A quiet waitress who hasn't been to work in two days vanishes without a trace; police suspect a date gone wrong.

The search for a missing exotic dancer led police to an isolated 75-acre site where someone had been shot and cremated, thus destroying all evidence... almost; piece of a foot provided enough DNA for a genetic profile and positive ID.

After years of suffering domestic abuse, a young woman is found murdered in her bathtub; among numerous clues, a hamburger bun proves the most incriminating.

Evidence that includes threatening emails, a missing person and an abandoned truck lead police to a woman's suspected killer, but they don't have the victim's body.

A woman has an accidental fall down a flight of stairs and appears to have hit her head, but the lack of blood splatter and misplaced shoes lead police to believe the fall was staged.

A church member gets gunned down after leaving choir practice; although witnesses see little and not much evidence exists, investigators learn that she had been having affairs for years.

New York police hunt the Zodiac killer after a series of deadly attacks.

When a healthy young man dies mysteriously in his sleep, toxicology tests reveal that it may have been foul play. Could a "suicide note" hold the key to solving the case?

A child's memory, a diary and a forensic psychologist help investigators solve a young woman's murder.

Investigators weigh several theories while probing the death of a retired police officer, including a botched robbery and suicide.

The bodies of two young women are found in the ashes of an apartment fire.

Two different men report the murder of a single mother and when the case's other anomalies stall the police, a candy wrapper and seeds help expose the killer.

After a Connecticut man's body is found in a burning rental car on a Mexican highway, an insurance company suspects a scam.

When a pipe bomb rips through a rural home, killing a young man and seriously injuring his mother, detectives hope that the remnants of a mailing label will lead them to a killer.

A quiet residential community, shattered by the murder of a neighbor. See how modern techniques helped investigators catch the culprit in less than 12 hours.

A man is found dead in his Michigan auto-salvage shop.

A man is murdered in a drive-by shooting. When a mobile phone trace incriminates a killer, it's up to a forensic geologist to find evidence that he was at the scene.

When a teenage girl is found dead, her boyfriend confesses to her murder. However, in a strange twist, so does another man; police must determine which is the killer.

A high school gym teacher gives his friend a ride home but never returns; his wife and friend receive letters saying he started a new life, but they suspect foul play despite no body being discovered.

A 16-year-old girl is killed in her own home by her mother and father. Her parents said they acted in self-defense, but the forensic evidence indicates otherwise.

Investigators determine if a computer crash which almost ruined a manufacturing company was accidental or deliberate sabotage.

Car with three Secret Service agents collides with local deputy's car; investigation launched into who was responsible for the deadly car accident finds two very different conclusions.

The derailment of the Sunset Limited was the deadliest train crash in U.S. history killing 47 passengers and crew with several more injured.

Arson investigators attempt to determine the cause of the 1987 fire at the Kings Cross Underground Station in London.

A discarded sleeping bag, containing bloody sneakers and a purse, leads police to the body of a young woman; a mark found on the victim's body enables police to track the killer.

A woman's apparent accidental death begins to look fishy after police uncover a letter written by the victim days before her untimely death.

An Alaskan trooper finds a woman's body beside a frozen road, but evidence is scant even after a suspected murder weapon is found.

Police link a clump of hair discovered in an isolated area with a woman who disappeared 20 years ago.

A news anchor is shot to death outside her home in an apparent crime of passion by a fan; a police dog tracks the scent of the killer back to the crime scene.

A fire, caused by an unattended cigarette, kills the estranged wife of a police officer; forensic scientists discover that the cause is far more complicated.

A trio of men, responsible for several bank robberies, leaves no evidence behind; forensic scientists help catch them by looking at the criminals' posture and clothing.

When a woman's bone marrow test reveals arsenic poisoning, investigators try to determine if it is due to groundwater contamination or something more sinister.

A missing bank president's body is found floating in a lake; the duct tape used in binding him to a chair helps solve the crime.

A husband was shot and killed, forensic psychiatry helped the wife to remember the details for what happened.

Stories from across the world and refreshing conversations with Audie Cornish.

Stories from across the world and refreshing conversations with Audie Cornish.

Melanie Zanona; Catherine Lucey; Isaac Arnsdorf.

When a man perishes in a fire while working in his garage, his death is initially ruled an accident until a forensic odontologist changes the direction of the case.

Lack of evidence compels investigators to look beyond the obvious when a woman is beaten to death at her in-laws house.

A man is found dead of an apparent suicide. But soon after, information emerges which reveals a much more menacing scenario.

A dismembered body is dumped on the side of the New Jersey Turnpike and before police realize it, bodies are turning up between two states.

A young bride-to-be is gunned down in her own home. The attack is personal and as investigators start digging, they uncover the man she loved was living a lie.

Tara Munsey went missing after a work shift at a Virginia restaurant, and it is unknown if she ran away or if she was the victim of foul play.

An Ohio woman and her two daughters go missing while vacationing in Florida; their corpses are found floating in Tampa Bay with a handwritten note by one of the victims; putting it on five billboards helps them find the killer.

Four young adults are murdered in an affluent Texas neighborhood, with little evidence but two people walking by dressed in black.

A young college student is found dead in her apartment and the autopsy rules the death a homicide by an unknown male suspect.

The killer removed the computer that links him to the murder of a woman and her soon-to-be ex-husband that he had met online.

A community is shocked when police discover a woman raped and murdered in broad daylight on a public trail.

A real estate developer is shot, and his wife becomes the prime suspect, until the bullet is linked to a weapon reported missing 20 years ago.

A body is found stuffed into a suitcase forcing the police to search though the landfill for another missing victim.

A woman goes missing for a month with the only clues being a set of keys, a fingerprint and a code.

The body of a 16-year-old girl is discovered nine months after her disappearance; forensic scientists find clues that paint a virtual portrait of her killer.

A young woman falls to her death in what appears to be a tragic accident; a forensic exam of photos taken at the scene tells a different story.

Haunted by her mother's long-ago disappearance, a woman undertakes an investigation of her own and stumbles upon a dark family secret.

The robbery and brutal murder of an elderly couple goes unsolved for 10 years; a forensic scientist makes history when he solves the crime.

A man is charged with the murder of a wrestling champion; six years later, a forensic animator testifies on his behalf.

A 19-year-old girl is found dead in her car in what appears to be a suicide; police discover that the victim was involved in a love quadrangle, giving several people motive to kill.

Fifteen years after a man disappears, using a metal detector, police find evidence which proves what had happened.

The body of a young California co-ed under an isolated interstate ramp sets off an investigation; San Diego police have no idea who would want her dead, but they discover a tiny, unique fiber on the victim's clothing.

Police become suspicious of a man who reported his wife missing 15 years after doing the same thing with his first wife.

While investigating the case of a Colorado hunter shot three times and killed, police suspect two murder weapons, and two killers, but forensic evidence points them closer to home.

A serial arsonist burns thousands of California homes and businesses.

A small community in upstate New York is devastated when a car accident claims the life of a well-respected nurse.

A woman disappears without a trace, and police learn two other women vanished under similar circumstances.

Hikers near Anchorage, Alaska discover a body wrapped in sheets edged in orange stitching; they discover threads of evidence clinging to the sheet.

The son of a murder victim contacts the police when a flight attendant is brutally murdered in a remarkably similar way.

A two-man shrimp boat sinks when a fast-moving, violent storm struck the Louisiana coast; a deckhand is considered a hero for trying to save the drowned captain, until his body is found.

A real estate tycoon must have had a premonition about foul play, as he wrote it in his will.

The cold-blooded murder of an American tourist in a Mexican resort causes law enforcement to focus on both sides of the border.

When a prominent banker's wife is kidnapped, the trail leads police on a wild goose chase; they track down disgruntled bank customers and examine computer fonts.

A man has no recollection of events after stabbing his wife and holding her head underwater in a swimming pool.

A fire investigator determines if a kerosene heater is the cause of a fire that killed one person or if it was murder.

California police in 1957 search for a murderer, but the case goes cold; 50 years after a crime is committed, advances in computer technology determine the killer.

Investigators piece together tiny clues at the scene of a hit-and-run accident; their findings help to track down the offending driver.

Investigators determine what caused a house fire that killed an elderly couple and whether the victims' son is responsible.

Detectives are suspicious after a woman is killed in a hunting accident, but it takes more than twenty years before a trace evidence analyst is able to match fibers on a soiled blanket to the killer.

When hunters find a skull in a Texas canyon, police find bits of clothing, a woman's shoe, some small bones and a strand of hair; once they discover her identity, it was time to find the killer.

A wife is missing in Key West; investigators wonder if they should be searching for a missing person or a killer.

Suicide notes and a pistol in hand lead police to suspect that a mother of two young children appeared to have killed herself, but when investigators learned of a house fire she was in three years earlier, they reinvestigated.

A mother puts her hope on the internet and an independent investigation to clear her name after authorities charge her with murdering her 17-month-old son in a fire considered to be intentionally set.

When a man dies unexpectedly in the office of a noted California doctor, police begin what they think will be a routine investigation, but discoveries of false identities and insurance fraud raise questions about the doctor's role.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

Police discover a mask near the crime scene and hope that it leads to the killer of a funeral director.

A killer assaults a young mother in her home, but despite meticulous washing of the crime scene, a single hair remains to lead authorities to the culprit.

The investigation into the disappearance of flight attendant Helle Crafts leads to the murder conviction of her pilot husband.

Scientists and detectives use DNA to solve a string of rapes and murders.

Police use DNA profiles of seed pods from a truck to catch a killer.

Police believe they have a serial rapist and murderer, but DNA testing and research leads to another arrest and conviction.

In 1976, 182 war veterans in Philadelphia become hospitalized with pneumonia-like symptoms and 29 die; the disease resurfaces every few years.

After a wealthy Southern physician gets murdered with a baseball bat, his wife and a handyman become convicted of the crime.

In 1971, John List disappears after murdering his mother, wife and three children; he eludes the law for years until an age-scaled sculpture of the suspect and a true-crime TV program helps lead to his arrest in 1989.

An 11-year-old boy comes down with a fever and diarrhea after eating an undercooked burger; when his condition worsens, his mother drives him to a hospital and doctors discover E. coli destroying his body.

Florida police search for a serial rapist and murderer who left small red fibers on each of his 10 victims.

When an English couple go missing, police suspect their son killed them and must rely on mud and blood samples found in the couple's two cars to find their bodies.

The violent death of an Air Force officer's wife outside a Philippines air base is examined, amid accusations of a love triangle involving the murdered woman's husband; investigators use groundbreaking computer forensics to make their case.

Pieces of plastic the size of sand hold clues to a bombing.

At first glance it appears a young woman suffocated, but further investigation shows the scene was staged.

A killer is careless when a home is destroyed by fire and a young boy is missing.

A patrol officer is shocked by the amount of blood at a traffic accident and is shocked by the coroner's ruling until an anonymous phone call re-ignites the case.

An irrigation canal murder remains unsolved until a similar murder occurs.

The light of day and DNA picture painted by molecular biologist reveals new clues about a nighttime traffic accident.

On Valentine's Day, an obstetrician finds his wife dead and calls 911; police discover inconsistencies between the blood spatter evidence and his version of events.

Weed analysis and photogrammetry are used to help solve the 1995 murder of a California teenager is found dead after disappearing from her home.

When police recover the submerged car of a missing man, they find no body; the investigation that follows uncovers a deadly obsession and the motive for murder.

Emergency dispatch received a call from a man who said his girlfriend shot and killed herself. But the wound was not self-inflicted.

Investigators piece together evidence found at the scene of a Native American woman's murder; the tire tracks and shoe impressions could lead them to the killer.

Experts seek answers to a young businesswoman's death just before she was to testify in a criminal trial.

An anonymous caller reports the rape and murder of a dry cleaner employee; two eyewitnesses tell two similar but not identical stories.

Police blame a botched robbery when an eccentric elderly millionaire is found dead, but the motive could be wrong.

Woman disappears from grocery store parking lot in Boulder, Colo.; investigators find extraordinary clues in a pair of bloody gloves, unique tire tracks, and ordinary grass and pine needles.

A car carrying three men pulls up alongside another on an Alaskan highway and fires shots, leaving a passenger dead; one of the passengers in the killer's car agrees to testify against his friends; the resulting trials don't end the carnage.

Police suspect a gay college student's slaying is a hate crime until forensic evidence points the case in another direction.

In a wealthy area of Philadelphia, police are called to the scene of what seems like a regular accidental drowning; the investigation begins to focus on one person who has many reasons to want the victim dead.

Two women are murdered in the same town and police fear a serial killer is on the loose, further investigation finds that they were both close to the same man.

A young woman is found dead on a golf course in the Bahamas; the grass on that course is so distinctive that it had evidentiary value; the evidence leads police to two suspects; each blamed the other, and they have to find out who the killer is.

A teenager goes missing after an evening of horseback riding; her body is found a month later, three miles from her home; the killer unknowingly leaves a trace of evidence behind, tiny but unmistakable clues that pointed to him and him alone.

When a popular disc jockey is found murdered in a community garden, police swing into action; a sniffer dog and a blood spatter expert led police to the killer, and he'd been much closer than they realized.

Investigators unravel a twisted tale of lust, greed and deception after a woman claims her husband was gunned down by intruders.

Three seemingly unrelated deaths proved to be serial murders; the killer had been careful, he used poison which had no taste or odour; fortunately for investigators, it also has a unique chemical signature.

A man is murdered in his sleep but no fingerprints are anywhere to be found; a shoe impression outside could lead to the killer.

With very little else to go on, investigators find that a show impression puts them on the right track to finding a killer in Lansing, Mich.

The owner of a restaurant is killed; investigators uncover tales of debt and deceit, but the case remains open, until one detective gets inspired by an earlier episode of "Forensic Files," and looks for clues in an empty holster.

A forensic scientist uses his skills to preserve a footprint left in snow to help authorities nab two men suspected of robbing an Ontario couple and shooting the husband in the head.

Fingerprints taken from a piece of cloth help solve the rape and murder of a 22-year-old woman in Henrico County, Va.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

Experts attempt to discover the source of heavy fog on Highway I-75 in Tennessee, which caused a 99-car accident and 12 deaths.

When a woman goes missing from her home, police focus on her husband when an airline luggage tag and luminol point to an affair and murder; footage from a TV crew and Coast Guard photographs lead investigators to the suspect's missing boat.

When a woman exhibits strange flu-like symptoms before dying, investigators discover someone added thallium to her soda; detectives initially suspect her husband, but the case takes a sinister turn.

Handwriting and simple doodles complicate a car-bomb case and an alleged self-defense shooting in a peaceful British farming village as police uncover a husband's plot to kill his wife for insurance money.

When dozens of infants develop serious breathing problems in the Cleveland area, doctors and investigators search high and low for the cause.

A well-liked bank vice president collapses and dies after taking pain pills laced with cyanide; the search for a motive reveals a callous suspect who had murdered once before.

Evidence reveals a teacher who complained of being stalked and harassed by another teacher was scamming police.

A man kills two people with bombs in an effort to get investors off his back, but authorities catch onto him, and he becomes sentenced to life with no chance of parole.

A man arrested for the sexual assault and attempted murder of a boy in a European country becomes linked to a murder in Zurich, Switzerland, through analysis of microorganisms.

Heavy rains and snow run-off carry manure into Milwaukee's water supply in 1993, leading to an epidemic of gastrointestinal illness affecting 400,000 people.

Autopsies reveal that a string of unexplained deaths in Omaha resulted from poison-induced liver disintegration.

In a series of murders near Sacramento, Calif., a killer gags and molests prostitutes, cuts their clothes in random patterns and cuts off their hair; microscopic evidence helps solve the case.

A serial arsonist was on the loose in Washington, DC. Each of the fires was started with the same type of incendiary device. The perpetrator was very careful, and seemed to leave no evidence behind... but there were clues in the ashes, and it was up to forensic scientists to find them.

A man becomes the prime suspect in his wife's death after forensic science raises questions about her apparent suicide.

Investigators on both sides of the Atlantic seek links between three homicides that look like professional executions.

Who put a bomb in the home of a 29-year-old woman and killed her?

A killer tried to destroy everything which could link them to the crime; but in doing so, they inadvertently created new forensic evidence, evidence which came to light using a technique never before used in a criminal investigation.

After a tycoon's wife is found dead in her SUV submerged in a half-frozen creek, police begin to suspect it wasn't an accident.

A Russian immigrant is found dead and a strange phone call to his office is the only lead investigators have.

Physical evidence initially condemns a prime suspect to a double homicide, but DNA from a discarded spoon points to another.

A young girl falls ill and dies; forensic investigators search for evidence halfway around the world to shed light on the tragic death.

Two bodies are discovered, shot to death in their car; the car windows are broken, but there's no sign of shattered glass.

Key suspect has a solid alibi in the murder of a war veteran; but police get a lead by finding a new suspect with a sweet tooth.

A woman who appeared to have taken her own life told her sister that, if anything were to happen to her, there was a note in the china cabinet.

When an aspiring model turns up dead, police suspect her boyfriend. But must dig deeper for clues when he is cleared.

Tiny fibers and an asthma inhaler are the clues that lead officers to the killer of an off-duty policeman.

Investigators search the world of high rollers and offshore betting to solve the first triple homicide in Verona, Wisc.

Police search every apartment building in town when the body of a young girl found on an isolated farm holds a set of keys but no ID.

A man denies killing a pedestrian in hit-and-run, claiming he sold the car in question; authorities track down the car to find critical evidence.

Three years later, a second autopsy determines who's right when a medical examiner and detectives disagree on the cause of death.