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Halstead and Manning's wedding day is interrupted when Halstead is forced to make a house call; Charles treats a woman who stabbed her husband; Choi and April deliver a breech baby; Rhodes and Bekker operate on an FBI witness.

A shooting outside the hospital injures April and leaves the ED shaken up; Halstead returns after a stint in the witness relocation program; Charles and Elsa have an emotional confrontation; Bekker is reluctant to attend an event honoring Rhodes.

Halstead takes heat for making an unauthorized move to treat his pregnant patient; Choi becomes personally invested when treating a homeless veteran; Rhodes and Bekker deal with a patient who desperately needs a liver transplant.

Manning and her three-year-old patient are trapped in a helicopter as the toddler's stats decline; Charles isn't sure Choi's alcoholic patient with liver failure has quite hit rock bottom.

Manning and Halstead must act fast to save the life of a physically abused wife; Choi and April are shocked to learn the truth about their 14-year-old cirrhosis patient; Rhodes and Lanik go head-to-head in the ER.

After a deadly chemical spill, the ED goes on lockdown, threatening the lives of several patients and leaving one of Med's own hanging in the balance; Rhodes and Manning must perform lifesaving surgeries.

Choi and Charles use trickery to help a patient with an itch she can't help but scratch; Halstead and Manning argue over a tattooed coma patient; Rhodes angers Goodwin by going against orders to save a patient in the hybrid OR.