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When a young woman looking to find herself on a solo trip to Hawaii vanishes without a trace, police race against the clock to find her before it's too late.

Two strangers meet while backpacking through Thailand, and sparks fly, but this budding romance in paradise ends in a horrific tragedy.

The most obvious suspect is not always guilty.

Strangled prostitute; a stranger kills a woman in a van; a serial killer runs over his victims' bodies.

Yingying Zhang, a scholar with a bright future, goes missing after entering a mysterious car; what investigators uncover stuns her community and points to an unimaginable crime.

In Seattle, a young woman vanishes and her phone goes dark. As strange texts confuse family and friends, detectives lean on digital forensics and a badly damaged cellphone to uncover what happened and who was really using her device.

Suspects will do anything to avoid being arrested, including hiding in strange places.

A woman with scarce medical history is found dead; a prescription drug addict is found dead with two empty pill bottles.

The body of a 16-year-old girl is discovered nine months after her disappearance; forensic scientists find clues that paint a virtual portrait of her killer.

A young woman falls to her death in what appears to be a tragic accident; a forensic exam of photos taken at the scene tells a different story.

Haunted by her mother's long-ago disappearance, a woman undertakes an investigation of her own and stumbles upon a dark family secret.

The robbery and brutal murder of an elderly couple goes unsolved for 10 years; a forensic scientist makes history when he solves the crime.

Police rely on forensic science to reveal murder victims' pasts and expose those guilty of committing crimes of passion.

Two brothers force a bank president to empty his vault before abducting him and throwing him off a bridge.

A man and his common-law wife go on a three-month killing spree that leaves eight people dead before they are apprehended by agents.

Police officer Brian Fanion frantically called 911 for an ambulance, saying his wife, Amy, had shot herself and lay dying; when Fanion's fellow officers arrived at the house, the crime scene posed more questions than answers.

A search mission for three women missing in Yosemite Park turns to a murder investigation when two are discovered in the trunk of their burned out car.

Nicole Abusharif, 26, murders her partner Rebecca Klein for the insurance money, then leaves her body in the boot of her car for a night of drinking with her young lover, Rose.

Law student Adrienne Hickson fatally stabs her boyfriend Shawn Washington with the knife for her birthday cake when he helps his friends move instead of spending the day with her.

Just outside Athens, Wis., Kenneth Kunz finds four of his family members murdered and one missing; investigators determine whether it was his mother, a local farm boy, or the rumored family drug dealing connections that led to the brutal slayings.

The bullet-ridden bodies of two sisters are discovered in a house littered with mysterious clues.

A task force forms to combat the flow of Colombian cocaine into New York ports.

David Snow, the man behind the murder of a young husband and wife.

Shortly before Thanksgiving, a Philadelphia suburb is rocked by the murder of 67-year-old Alice Hufnagle.

Todd, a 17-year-old with learning disabilities, becomes obsessed with his special education teacher, Linda.

In Northport, Wash., the townspeople come to realize that isolation doesn't guarantee their safety when a 62-year-old woman is found murdered in her home at Thanksgiving.

Bare-bottomed bandits and partly clad party girls; a dozing drunk driver gets caught with his pants down; amateur strippers give officers a peep show; a drug-crazed nudist resists arrest.

An octogenarian hits 50 mph driving the wrong way on a freeway; a legendary bank robber holes up in her motor home, triggering a standoff; a gun-toting crook is overmatched by a little old lady.

Forensic scientists must work to prove murder when the victim's body is missing or destroyed.