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Jessica is brought into the case of a murdered financier and the theft of his wife's diamonds in Monaco.

Four of five teen brothers are gunned down separately over a six-year period, beginning in 1999. After the latest shooting, Lilly reopens the other three unsolved cases and recalls that the 1999 murder was her first homicide investigation. The probe reveals that the brothers were involved with dangerous gangs and that revenge may have played a factor in their deaths.

Lilly and Valens travel to West Virginia to escort back to Philadelphia a suspected murderer who is believed to have abducted a woman from her 2007 engagement party and then killed her.

The 1997 murder of an ex-con is investigated when the victim's severed hand is discovered during a drug bust. The arrested drug dealer claims he found the ex-con already dead, cut off the hand and disposed of the victim's body. He used the hand to sell fingerprints.

The 1962 death of a woman who was thought to have committed suicide is investigated after new evidence brought in by the deceased's granddaughter proves she was murdered.

In the fifth-season finale, a former drug addict claims to have seen her son---who supposedly perished in an apartment fire three years earlier---playing in a park. Priscilla Chapin: Nicholle Tom. James McElroy: Erik Van Wyck. Victor Martinez: Julio Oscar Mechoso. Franklin Palmer: Chandler Parker. Eddie: Bobby Cannavale.

Arriving sailors celebrate in Boston during the city's Fleet Week, yet it isn't smooth sailing when the body of a young girl is found. Also arriving is Frost's father (Ernie Hudson), a Navy admiral who stirs up tension with his son. Meanwhile, Maura heads out on a date with Angela's mechanic (Matthew Del Negro).

Previous cases come up for review when an LAPD crime lab is discredited. One such past case involves Provenza and his ex-partner (Beau Bridges), who emerges from retirement to help revisit the investigation. The busy case reviews also threaten to undo Brenda and Fritz's planned vacation.