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22-year-old Tierra has lumps on her ears that require medical attention. Plus, Dr. Zoe helps Dr. Lee with a patient with numerous head bumps.

Dr. Lee meets a patient with a big bump on his forehead. Plus, 30-year-old Shelby has developed mysterious bumps all over her body.

Gerald returns to see Dr. Lee and a hand specialist about a huge, intrusive bump on his finger. Vinnie has an embarrassing birthmark on his neck.

Tanisha had a traumatic upbringing, suffering abuse from men. Like her super-obese drug addicted mum, she sought protection in food and her life is at risk.

Weighing 791-lbs, James is bedridden, unable to stand, and can barely move his legs. He may only have a few months to live. Can bypass surgery save his life.

Nasreen travels from Dubai with only a few days to find her dream dress, whilst Kayleigh has a princess-style ball gown in mind but it has to be perfect.

Josie is frustrated when her sister and sister-in-law disagree over her wedding dress. Bronnie dreams of a modern sexy gown, but mum prefers a princess style.

Bride Amy wants a sparkly dress to flaunt her figure after losing seven stone. Nellie is engaged for the second time and wants a lace gown to outshine her first.

Emma seeks a fairytale gown to match her wedding, but will dad and David see eye to eye? Meanwhile, tomboy Emma steps outside her comfort zone and into a gown.

When Peggy and Molly have lunch together, Mike worries that his mum is telling Molly unflattering stories about his childhood.

Mike and Carl's annual pilgrimage to the Chicago Cubs' Opening Day is interrupted when Molly comes along.

When Samuel loses his job and apartment, Mike offers to let him stay at his place - with interesting results.

Inspired by his hero, Albert Einstein, Sheldon tries his hand at the violin. Also, Mary and Meemaw secretly buy a pregnancy test.

Sheldon moves in with Dr. Sturgis for the weekend to experience college life. A lonely Mary tries to bond with the other Coopers during his absence.

Unhappy that school funds are going toward football rather than academics, Sheldon decides to run for class president.

Howard discovers that he can't escape his mother - even in space! Back on earth, meanwhile, Raj turns his existence as a third wheel into an art form.

After learning Penny is thinking about breaking up with Leonard, Sheldon tries to intervene. Howard is being picked on in space by the astronauts.

While the pressure of being in space starts to take its toll on Howard, Amy feels threatened when Sheldon hires a young female assistant, Alex.

When Howard returns from space, he doesn't get the hero's welcome he expected. Meanwhile, Game Night turns into a battle of the sexes.

The gang celebrates Halloween at Stuart's comic book store. Leonard and Penny discover a new spark in their relationship with a scientific seduction.

Sheldon's friendship with renowned scientist Stephen Hawking is threatened by a game of 'Words with Friends.

Bernadette pressures Howard to move out of his mother's house. Sheldon finds himself caught in the middle of a fight between Amy and Wil Wheaton.

Howard and Raj try to understand why Sheldon disappears every afternoon at 2:45. Leonard and Penny wrestle with jealousy in their relationship.

When Joyce invites Vince to attend her high school reunion, he confesses to Mike that he never graduated high school.

Victoria panics as her 30th birthday approaches - and drags Mike and Molly into the drama of her life crisis.

Mike feels pressured when Peggy's new boyfriend asks whether he and Molly hear wedding bells in their future.

Georgie is thrilled when Veronica stays at the Coopers' for a few days. Meanwhile, Meemaw and Dr. Sturgis celebrate their one-year anniversary.

The Coopers help a broken-hearted Pastor Jeff through a rough patch in his marriage. Meanwhile, Sheldon pressures church members for donations.

Sheldon invites the entire school to a party for the Nobel Prize announcements. Meanwhile, Meemaw learns more about Dr. Sturgis's past.

When the University reassigns Sheldon's unused parking spot to Howard, the ensuing turf battle affects the whole gang.

Sheldon plays nursemaid to a sick Amy, while Howard attempts to bond with his father-in-law on an upcoming fishing trip.

Sheldon unwillingly revisits some Christmas memories during a lively game of Dungeons and Dragons, while Raj joins the girls for ladies' night out.

Sheldon is accused of sexual harassment at the University and winds up dragging Leonard, Raj and Howard into the fray.

Leonard's car is stolen when the guys take a road trip to a comic book convention in Bakersfield, dressed as Star Trek characters.

Outraged that he's being forced to work with his university nemesis, Barry Kripke, Sheldon faces a crisis of conscience.

When Sheldon and Leonard fight, it affects Penny and Amy's living arrangements. Meanwhile, Raj takes care of Mrs. Wolowitz while Howard is away.

While the guys try to give their significant others the perfect Valentine's Day, Raj and Stuart throw a lonely people party at the comic book store.

Emma comes clean on her birthday. Jovon heads to Anna's hometown. Lisa confronts Daniel about another woman, and Stig reassesses his relationship.

Two Idiots On A Dirt Bike. Georgie's attempt to break up Missy and her new boyfriend backfires, with severe consequences.

Mandy tries to prove she's financially responsible after being called out on her poor spending habits, and Connor's girlfriend needs a place to stay.

Lee Nose Best! Tony has large growths on his nose that impair his breathing. Can Dr. Lee help? And, Marie has an unsightly lump on her forehead that makes her a hermit.

Cystem Shutdown! Gerard has nearly a hundred lumps varying in size all over his body. Eric has a large bump on his head that he calls his 'on/off button.

Steven And Justin's Story Part 1. Steven weighs 800-lbs and his brother, Justin, 600-lbs. Desperate to save both his sons' lives, their father travels across the US to seek help.

Steven And Justin's Story Part 2. After a year on a weight loss programme, Steven is non-compliant, and Justin focuses on a new career instead of his diet. Time is running out.

Glamour model Danielle Lloyd is marrying for a second time and won't repeat the same dress mistakes! Jade tries a giant princess dress, but wants a sexy frock.

Nana is Ghanaian royalty and is running out of time to find her wedding gown, whilst Claire seeks something simple for her Windsor Castle wedding.

Best friends Alice and Katie go wedding dress shopping together. One wants a classical gown, and the other seeks a shorter frock to wear with trainers. Can David help.

Sophia wants a beaded dress hinting at her Pakistani and Cypriot heritage, and Chengetai seeks 'two-in-one' dress with a detachable skirt. Will her picky mum approve.

When Meemaw gives Sheldon his first video game, it takes over their lives. Meanwhile, George Sr. gets jealous when Georgie bonds with Herschel.

Sheldon studies his family for a psychology project when their Thanksgiving dinner turns into a fight after George Sr. is offered a job in Oklahoma.

When Sheldon learns that stunted childhoods can turn people into outcasts, he tries to act his age. Meemaw and Dr. Sturgis's relationship is tested.

While Missy unknowingly becomes Sheldon's test subject, Georgie joins Mary's Bible study to spend more time with his crush, Veronica.

When Sheldon has to spend a few days in the hospital, he turns into the world's worst patient, and his behaviour takes a toll on everyone.

While Sheldon attempts to build a nuclear reactor to power the neighbourhood, Georgie is heartbroken when he learns that Veronica has a boyfriend.

Two Idiots On A Dirt Bike. Georgie's attempt to break up Missy and her new boyfriend backfires, with severe consequences.

Mandy tries to prove she's financially responsible after being called out on her poor spending habits, and Connor's girlfriend needs a place to stay.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Penny worries that she's screwed things up permanently with her friends after her night with Raj, while Sheldon takes command of the paintball team.

Leonard and Amy get to know each other better at a co-worker's wedding. Howard and Bernadette spend the weekend with Mrs. Wolowitz.

Raj is upset he's the only one of the four guys who's not in a relationship, so Penny sets out to find the perfect date.

Sheldon and Leonard get invited to a housewarming party at Wil Wheaton's house. Howard gets an out-of-this-world opportunity.

Craving a little motherly love, Sheldon competes with the gang for his mother's attention when she comes to visit.

A cute comic book artist tests Leonard's relationship with Priya, while Sheldon, getting into the Halloween spirit, tries to scare the guys.

Amy is heartbroken when Bernadette and Penny go shopping for wedding dresses without her.

Can friends with benefits still be friends without? Leonard and Penny try hanging out alone, while Sheldon must overcome his fear of birds.

Sheldon becomes jealous and considers taking his relationship with Amy to the next level when Stuart from the comic book store asks her out on a date.

Leonard must face his fears after being contacted by his high school tormentor, while Penny realises that she might have been a bully herself.

Sheldon gets in trouble with Amy, and it's up to Penny to teach him how to be a better boyfriend. Howard deals with Bernadette's dislike of children.

Everything might change when Leonard offers Penny a spur of the moment invitation to a romantic dinner for two on the 100th episode of the series.

Leonard and Penny experiment with dating again by 'beta testing' their relationship. Raj develops a weird bond with his phone's virtual assistant.

Sheldon's selfish demands force Leonard to reconsider their friendship. Meanwhile, Howard tries to pick his astronaut nickname.

When Sheldon is forced to take a vacation by the university, he goes to work with Amy in her neurobiology lab.

When a corner office at the university opens, Sheldon must compete for it with his office nemesis, Barry Kripke. Penny gets an unusual gift from Amy.

A change in Sheldon's routine forces him to re-evaluate his entire life, when his barber is sick. Howard rethinks his decision to go into space.

Sheldon chooses to participate in a guys-only weekend Star Wars gaming marathon rather than go with Amy to her aunt's birthday party.

It's a dream come true for Sheldon when he has a close encounter with his hero, Mr. Spock -legendary sci-fi icon Leonard Nimoy.

Dara Ó Briain is joined by Rhys James, Alasdair Beckett-King, Ed Byrne, Janine Harouni, Hugh Dennis and Ellie Taylor to examine the week's events.

Hijinks ensue as Street-smart Detroit cop Axel Foley returns to L.A. to help his buddies on the force solve a series of unusual robberies.