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Frankie's parents, Pat and Tag, come to town to spend the holiday with the family much to Mike's dismay.

After years of never having time for themselves, Frankie and Mike decide to take charge of their lives and regain control over the Heck household.

Mike freezes Frankie out because he can't fathom how she inadvertently paid $200 for a small bottle of eye cream that she thought was priced at $20.

While Mary's away, George finds himself giving advice on Missy's love life. And Georgie has a solution for Meemaw's business woes.

While Missy asks some uncomfortable questions about sex in church, Meemaw and Georgie go into business together.

Sheldon takes his first engineering class with Professor Boucher. Meanwhile, Meemaw and Dale help take care of his ex-wife, June.

Sheldon's visit to see his mummy forces him to start addressing a new reality. The gang speculate about where they might be in 20 years.

Raj wrestles with dating two women at the same time, Penny is offered a part in a trashy movie, and Sheldon can't decide between two gaming systems.

Raj and Howard double-date, and the latter is flushed with embarrassment after Raj's girlfriend reveals a secret she knows about Howard.

Leonard reinstates Anything Can Happen Thursday, and Sheldon attempts something spontaneous. Raj requests help from Howard in prepping for a date.

Sheldon receives counselling from his childhood TV idol, while Penny and Leonard reach a relationship milestone and turn it into a competition.

A trying day at the movie shoot makes Penny question her life choices. Caring for a bedridden Mrs. Wolowitz is a challenge for Howard and Bernadette.

Sheldon gets caught up in all the life-altering changes going on around him and considers a monumental move. Raj and Emily take it to the next level.

Amy and Leonard take a road trip, Penny has an interview at Bernadette's company, and Howard has issues with Stuart's relationship with his mum.

As the Super Bowl approaches, Mike is thrilled when Brick takes his advice and studies up on football - leading Axl to get jealous of his brother.

Frankie is elated when Axl asks her to accompany him to help pick out a present and choose a restaurant to impress his new girlfriend.

Fearing that a friendless Brick could be missing out on his childhood, Frankie makes it her mission to find a suitable friend for him.

While Sheldon battles the mysterious Grand Chancellor of the university over science requirements, Mary makes a shocking discovery about Georgie.

While George Sr. plays handyman at Brenda Sparks' house, Sheldon gets the science yips and has to learn how not to think.

Sheldon gets a dorm room all to himself, which soon becomes the campus hotspot. Meanwhile, Meemaw gets an unwanted business partner.

Howard signs up to take Sheldon's class, and tensions between Penny and Bernadette give Amy an opportunity to play one against the other.

NASA asks Wolowitz to throw the first pitch at an Angels baseball game. And Sheldon says that he and Amy are a better couple than Leonard and Penny.

Raj's girlfriend gives Penny the cold shoulder after he tells her about their history, and the guys consider buying into Stuart's comic-book emporium.

Amy and Bernadette accuse Penny of becoming a party pooper. And the guys brainstorm about inventing something cool.

Sheldon and Raj go on an expedition that turns into a test of how long before they get under each other's skin. Leonard and Penny argue about money.

Penny's sales pitch leaves a doctor-client smitten and the guys help her deal with it, and Bernadette and Amy debate female scientists and sexuality.

Amy and Bernadette organise a prom to be held atop the guys' apartment complex, but Sheldon is leery of all the prom pomp, circumstance and romancing.

Leonard needs surgery for a deviated septum, and Sheldon feels an operation is too dangerous and that his roommate may not make it out alive.

Mark's hands are 20 times bigger than normal. After learning that his condition may require amputation, Mark stopped seeing doctors.

Destinee & Dynastiee - Part 1. Identical twins Destinee and Dynastiee weigh over 1200 pounds combined. They determine to get healthy and lose weight together with Dr. Now's help.

Dr. Lee meets Dot, who has a large lump growing on her inner thigh. Plus, a new doctor helps 68-year-old Tim with his severe rhinophyma.

As the Super Bowl approaches, Mike is thrilled when Brick takes his advice and studies up on football - leading Axl to get jealous of his brother.

Frankie is elated when Axl asks her to accompany him to help pick out a present and choose a restaurant to impress his new girlfriend.

Fearing that a friendless Brick could be missing out on his childhood, Frankie makes it her mission to find a suitable friend for him.

Katrina suffers from oozing, smelly boils that have appeared all over her body. Plus, a patient with Neurofibromatosis seeks help from Dr. Lee.

At over 600-lbs each, Vianey and Allen are in a co-dependent relationship based on a shared love of food. Can they conquer their food addiction together.

Bride Lara beat a brain illness but the weight she gained makes dress shopping a trial - can David rebuild her confidence? Plus, tomboy Katie wants a young, fun frock.

Bride Samantha wants a dress with bling, but the one she wants is double her budget at $12,000. Krystina and her opinionated mum can't agree on style.

As the Super Bowl approaches, Mike is thrilled when Brick takes his advice and studies up on football - leading Axl to get jealous of his brother.

Frankie is elated when Axl asks her to accompany him to help pick out a present and choose a restaurant to impress his new girlfriend.

Fearing that a friendless Brick could be missing out on his childhood, Frankie makes it her mission to find a suitable friend for him.

While Sheldon battles the mysterious Grand Chancellor of the university over science requirements, Mary makes a shocking discovery about Georgie.

While George Sr. plays handyman at Brenda Sparks' house, Sheldon gets the science yips and has to learn how not to think.

Sheldon gets a dorm room all to himself, which soon becomes the campus hotspot. Meanwhile, Meemaw gets an unwanted business partner.

Howard signs up to take Sheldon's class, and tensions between Penny and Bernadette give Amy an opportunity to play one against the other.

NASA asks Wolowitz to throw the first pitch at an Angels baseball game. And Sheldon says that he and Amy are a better couple than Leonard and Penny.

Raj's girlfriend gives Penny the cold shoulder after he tells her about their history, and the guys consider buying into Stuart's comic-book emporium.

Amy and Bernadette accuse Penny of becoming a party pooper. And the guys brainstorm about inventing something cool.

Sheldon and Raj go on an expedition that turns into a test of how long before they get under each other's skin. Leonard and Penny argue about money.

Penny's sales pitch leaves a doctor-client smitten and the guys help her deal with it, and Bernadette and Amy debate female scientists and sexuality.

Amy and Bernadette organise a prom to be held atop the guys' apartment complex, but Sheldon is leery of all the prom pomp, circumstance and romancing.

Leonard needs surgery for a deviated septum, and Sheldon feels an operation is too dangerous and that his roommate may not make it out alive.

After Sue wins a family trip to New York, Murphy's Law goes into full effect and it's anything but a smooth flight when the family boards the plane.

Frankie quarrels with Brick's teacher, Ms. Rinsky, when Brick gets a 'D' on his math test and Frankie thinks bad teaching skills are to blame.

Spring Break turns out to be anything but peaceful when the family attempts to clean up 20 years of junk accumulated throughout the house.

Sheldon acts as Mary's spy when he's forced to spend the night at church for a youth lock-in. Meanwhile, Georgie gets attracted to an older woman.

Sheldon attends his first comic book convention, and Mary tries selling makeup.

Sheldon makes friends with his dorm neighbours. Meanwhile, George Sr. learns his job is in jeopardy.

Sheldon bids farewell to his Fun With Flags podcast. Leonard, Howard and Raj probe a late professor's research in search of some hidden significance.

Amy plans a Victorian dinner for Christmas Eve, while Raj, Leonard and Howard try to remove a pigeon that flew into the clean room at the university.

Raj awaits data from a space probe in which he was involved. Later, Leonard and Sheldon go dress shopping with Penny and Amy.

Sheldon becomes concerned that his cushy lifestyle is impacting his professional progress, so he asks the gang to make life more difficult for him.

An online troll rips Leonard and Sheldon's physics paper, and a girls' night out leads to Penny, Amy and Bernadette dishing about embarrassing events.

Howard gets unsettling news amidst the excitement of the comic book store reopening, and Penny doesn't practice what she preaches.

An experiment designed to make people fall in love piques Penny and Leonard's interest. Meanwhile, Leonard, Amy, Raj and Emily encounter a 'zombie.

There's trouble in paradise when Amy learns Sheldon signed up for a one-way mission to colonise Mars. Leonard makes an 'adult' purchase for Penny.

Ed Gamble, Richard Ayoade and Joanne McNally welcome some brilliant guest comedians to share their wild, unwise or downright unacceptable opinions.

A moronic mob bagman, his noisy girlfriend, and a closeted gay hit man all collide on a trip to Mexico to recover a supposedly cursed gun.

After Sue wins a family trip to New York, Murphy's Law goes into full effect and it's anything but a smooth flight when the family boards the plane.

Frankie quarrels with Brick's teacher, Ms. Rinsky, when Brick gets a 'D' on his math test and Frankie thinks bad teaching skills are to blame.

Spring Break turns out to be anything but peaceful when the family attempts to clean up 20 years of junk accumulated throughout the house.

22-year-old Tierra has lumps on her ears that require medical attention. Plus, Dr. Zoe helps Dr. Lee with a patient with numerous head bumps.

Estranged brothers John and Lonnie are complete opposites. Now, they're united by their need to lose weight while they still can - and save their relationship.

Steph wants a mermaid dress for her beach wedding, but her mum wants her princess-like in a ball gown! Christina is back for her first fitting - will mum approve.

While Randy is in Barcelona showing his second collection, Chelsea's princess dress goes missing and bride Cheryl finds fault with every gown she sees.

After Sue wins a family trip to New York, Murphy's Law goes into full effect and it's anything but a smooth flight when the family boards the plane.

Frankie quarrels with Brick's teacher, Ms. Rinsky, when Brick gets a 'D' on his math test and Frankie thinks bad teaching skills are to blame.

Spring Break turns out to be anything but peaceful when the family attempts to clean up 20 years of junk accumulated throughout the house.

Sheldon acts as Mary's spy when he's forced to spend the night at church for a youth lock-in. Meanwhile, Georgie gets attracted to an older woman.

Sheldon attends his first comic book convention, and Mary tries selling makeup.

Sheldon makes friends with his dorm neighbours. Meanwhile, George Sr. learns his job is in jeopardy.

Sheldon bids farewell to his Fun With Flags podcast. Leonard, Howard and Raj probe a late professor's research in search of some hidden significance.

Amy plans a Victorian dinner for Christmas Eve, while Raj, Leonard and Howard try to remove a pigeon that flew into the clean room at the university.

Raj awaits data from a space probe in which he was involved. Later, Leonard and Sheldon go dress shopping with Penny and Amy.

Sheldon becomes concerned that his cushy lifestyle is impacting his professional progress, so he asks the gang to make life more difficult for him.

An online troll rips Leonard and Sheldon's physics paper, and a girls' night out leads to Penny, Amy and Bernadette dishing about embarrassing events.

Howard gets unsettling news amidst the excitement of the comic book store reopening, and Penny doesn't practice what she preaches.

An experiment designed to make people fall in love piques Penny and Leonard's interest. Meanwhile, Leonard, Amy, Raj and Emily encounter a 'zombie.

There's trouble in paradise when Amy learns Sheldon signed up for a one-way mission to colonise Mars. Leonard makes an 'adult' purchase for Penny.

Mike punishes Axl for his mess by forbidding him to play in the last game of the season, but everyone assumes that Mike has an ulterior motive.

Obsessed with the upcoming royal wedding, Frankie shocks her family when she treats the event like the Super Bowl.

Mother's Day for Frankie turns out to be anything but serene when Mike and the kids present Frankie with the perfect gift - a day to herself.

When a new scientist, Dr. Lee, joins the lab, Sheldon is the odd man out. Meanwhile, Mary is given a lotto ticket.

Sheldon joins Dr. Linkletter and Dr. Sturgis on a science road trip, landing them in the middle of nowhere. Georgie continues to lie about his age.

When Meemaw's gambling room is a success, she ends up with a suitcase of illegal cash. Missy starts a business, and Sheldon tries the stock market.

An electrical short thaws the last meal cooked by Mrs. Wolowitz, and Sheldon and Leonard's work is featured in a magazine, but only one gets credit.

Leonard and Sheldon consider dropping by George Lucas' Skywalker Ranch when a speaking engagement puts them nearby.

Sheldon and Amy reach a crossroad, a man claiming to be Wolowitz's half-brother shows up, and Penny and Leonard argue live on Wil Wheaton's podcast.

NASA asks Raj to craft a message for aliens in the event of contact, and Penny must choose between an audition or her job in pharmaceutical sales.

Wolowitz and Sheldon can't get a drone to fly, Leonard nearly misses giving a commencement address, and Raj pits his parents against each other.

Leonard and Sheldon's mothers come to town to celebrate their sons getting an award, but the opinionated women engage in an altercation over religion.

Leonard and Penny are pressured to set a wedding date by Sheldon, whose relationship with Amy has taken an interesting turn.

Penny has a problem dealing with Leonard's confession about having kissed another woman, while Sheldon is confused about Amy calling a time out.

Edward struggles to fit in with Marissa's friends, Catie's mum is concerned about her recent behaviour, and Anabelle offends Shea's daughter.

Dr. Lee meets a patient with a big bump on his forehead. Plus, 30-year-old Shelby has developed mysterious bumps all over her body.

Mike punishes Axl for his mess by forbidding him to play in the last game of the season, but everyone assumes that Mike has an ulterior motive.

Obsessed with the upcoming royal wedding, Frankie shocks her family when she treats the event like the Super Bowl.

Mother's Day for Frankie turns out to be anything but serene when Mike and the kids present Frankie with the perfect gift - a day to herself.

Anthony's thigh lump blocks his fresh start, while Mary's 70-year-old bump shocks doctors. Plus, Sultana's rash threatens her success and confidence.

Lindsey seemed to have it all - but her food addiction threatens to ruin everything. As she starts her weight loss journey, is her husband a support or an addict.

Nasreen travels from Dubai with only a few days to find her dream dress, whilst Kayleigh has a princess-style ball gown in mind but it has to be perfect.

Bride Rebecca has lost 90-lbs and won't let her mum keep her from her dream dress. Plus-size Cassidy craves a Hayley Paige gown - can it live up to the hype.

Sheldon encourages Missy to question the Bible. Meemaw determines to catch George Sr. in a lie, and Mary helps Pastor Jeff search for a youth pastor.

While Sheldon tries to convince Dr. Sturgis to return to the university, Georgie upsets the family when he makes a life-changing decision.

Pish Posh And A Secret Room. While Meemaw opens a secret gambling room, Sheldon, Missy and Georgie adapt to new living arrangements.

While Mary's away, George finds himself giving advice on Missy's love life. And Georgie has a solution for Meemaw's business woes.

While Missy asks some uncomfortable questions about sex in church, Meemaw and Georgie go into business together.

Sheldon takes his first engineering class with Professor Boucher. Meanwhile, Meemaw and Dale help take care of his ex-wife, June.

While Sheldon battles the mysterious Grand Chancellor of the university over science requirements, Mary makes a shocking discovery about Georgie.

While George Sr. plays handyman at Brenda Sparks' house, Sheldon gets the science yips and has to learn how not to think.

Amy and Leonard try to help Sheldon when his accidental scientific discovery is disproved. Howard and Bernadette open their home to Raj for a week.

With Sheldon in Texas, the gang decorates for Christmas, and they each contemplate if they would have had a wonderful life if they'd never met him.

Penny turns to Leonard after her guest appearance doesn't turn out well. Sheldon works on his sense of humour, and Raj practices talking to girls.

Penny makes a big step toward pursuing a full-time acting career, and Sheldon is forced to take a vacation.

Unable to score tickets for Comic-Con, Sheldon decides to stage his own comic-book convention, while the ladies attempt to act like grown-ups.

Amy talks Sheldon into a romantic Valentine's Day getaway to Napa Valley. Leonard and Penny make an emergency visit to the vet with Raj's dog.

Leonard's purchase of a new dining room table doesn't sit well with Sheldon, and Bernadette isn't happy about Howard taking another trip to space.

Things turn rocky between Sheldon and Wolowitz, and Bernadette steps in to mediate. Penny is offered a movie role that may prove embarrassing.

Sheldon's visit to see his mummy forces him to start addressing a new reality. The gang speculate about where they might be in 20 years.

Raj wrestles with dating two women at the same time, Penny is offered a part in a trashy movie, and Sheldon can't decide between two gaming systems.

Raj and Howard double-date, and the latter is flushed with embarrassment after Raj's girlfriend reveals a secret she knows about Howard.

Leonard reinstates Anything Can Happen Thursday, and Sheldon attempts something spontaneous. Raj requests help from Howard in prepping for a date.

Sheldon receives counselling from his childhood TV idol, while Penny and Leonard reach a relationship milestone and turn it into a competition.

A trying day at the movie shoot makes Penny question her life choices. Caring for a bedridden Mrs. Wolowitz is a challenge for Howard and Bernadette.

Sheldon gets caught up in all the life-altering changes going on around him and considers a monumental move. Raj and Emily take it to the next level.

Amy and Leonard take a road trip, Penny has an interview at Bernadette's company, and Howard has issues with Stuart's relationship with his mum.

Howard signs up to take Sheldon's class, and tensions between Penny and Bernadette give Amy an opportunity to play one against the other.

NASA asks Wolowitz to throw the first pitch at an Angels baseball game. And Sheldon says that he and Amy are a better couple than Leonard and Penny.

Raj's girlfriend gives Penny the cold shoulder after he tells her about their history, and the guys consider buying into Stuart's comic-book emporium.

Amy and Bernadette accuse Penny of becoming a party pooper. And the guys brainstorm about inventing something cool.

Dr. Lee treats Reginald, who has a rare growth on the back of his head. Che'Re has a prominent bump on her face, and Juan has painful boils on his neck.

Dennis has several giant growths on his head. Juan has a rare condition he hopes Dr. Lee will understand. Natalie is covered in hundreds of mysterious dark bumps.

Don't Sweat It! Audrey pops the painful bumps on her body so she can feel relief. Krista's excessive sweating is so severe that she could fill up an entire milk jug with her sweat.