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Inoke has a huge and potentially life-threatening bulge on his shoulder. Delano returns to see Dr. Lee and Reed has hundreds of bumps all over his chest.

When Peggy's depressed friend Kay returns to town, Molly is determined to find a way to lift her spirits.

Mike meets his Aunt Rosemary for the first time and is instantly smitten by her warmth and positive attitude, which is the opposite of his mother.

With pandemic safety protocols in place, Dr. Lee reopens her office. Patients include Monica, who has a large birthmark growing on the side of her face.

Shakyia's older sister rallies her to meet Dr. Now and lose weight. But she's in for a shock when her mum decides that caring for her is too much.

Bride Krystle shares the spotlight with her mum, Kathy. Afrodite and her mum argue over fashion. Plus Lindsey wants her mum to attend the fitting.

Katie's sister convinces Katie to ditch her tomboy look. Courtney searches for a ball gown. And Jennifer orders a dress too small for her, in order to lose weight.

Amy bought a gown elsewhere but changed her mind and now she's hunting for her dream dress and Michelle is viewing her dress after losing 50 pounds.

Jacqueline explains that she would like two different style dresses for her wedding. Meanwhile Christina is at the salon for her second dress fitting.

Georgie's jealousy rears its head when Mandy gets sent on an overnight work trip with boss, who also happens to be her ex.

Audrey and Mary's feud rears its head when Georgie needs their help with the tyre store, and Jim's forced to confront his age after visiting the DMV.

The university tries to recruit Sheldon, through George. Georgie gets a job working for Meemaw's new boyfriend. Mary decides to rid her home of greed.

Mary gets Pastor Jeff involved when Sheldon isn't invited to Billy's birthday party. George, meanwhile, has 'male-bonding time' with Dr. Sturgis.

Sheldon fakes being sick to avoid a swim test at school. Meanwhile, Dr. Sturgis spies on Meemaw's new boyfriend.

George and Meemaw struggle to manage the Cooper household while Mary plans Pastor Jeff's wedding.

When Sheldon and Leonard fight, it affects Penny and Amy's living arrangements. Meanwhile, Raj takes care of Mrs. Wolowitz while Howard is away.

While the guys try to give their significant others the perfect Valentine's Day, Raj and Stuart throw a lonely people party at the comic book store.

After a terrible date, Raj vows to never leave his apartment again. Meanwhile, Penny actually impresses Sheldon with her acting skills.

Leonard, Sheldon and Howard try to advance the cause of women in science by speaking with junior high girls about their future careers.

When Howard finds a letter from his father, he's forced to confront his past. And Leonard and Penny throw a grown-up cocktail party at the apartment.

Let the battle begin! Leonard, Sheldon and Raj fight for tenure at the University - and the competition heats up when the girls get involved.

After one of his favourite TV shows gets cancelled too soon, Sheldon feels lost, so Amy tries to help him get over his compulsive need for closure.

Leonard and Sheldon hire Professor Proton, the host of their favourite childhood TV show, to perform. Raj leaves his dog with Howard and Bernadette.

Georgie and Mandy get upset when Audrey disciplines CeeCee without their permission.

Georgie's feud with a rival store threatens his partnership with Ruben. Meanwhile, Mandy finds out Georgie's been keeping secrets from her.

Sheldon catches a struggling Paige shoplifting. Meanwhile, George Sr. is furious when Georgie tries to buy his way out of chores.

George and Georgie go camping with Meemaw's new boyfriend, Dale, but things get complicated when her ex-boyfriend tags along.

Sheldon and Georgie bond over a money-making opportunity. Meanwhile, Mary is concerned when Missy misuses religion.

Meemaw meets Dale's ex-wife, while Sheldon is forced to work on a group project with reluctant college students.

When the girls' trip to Vegas falls through, the guys invite them to a Dungeons & Dragons date. Meanwhile, Raj and Lucy go on an awkward date.

When Leonard is offered an exciting new job opportunity overseas, Sheldon grows jealous. Raj pushes Lucy a little too far in their relationship.

Leonard is away at sea, so Sheldon and Penny spend time together and spill some revealing secrets. Howard comes to Raj's aid after a breakup.

Leonard returns from his expedition and finds things chilly between him and Sheldon, and Howard faces questions about his masculinity.

Raj puts together a scientific scavenger hunt that turns into serious, cutthroat competition that brings out the best - and the worst - in the gang.

Amy ruins one of Sheldon's favourite films. Leonard discovers how to get Penny to do his bidding. Raj and Stuart get creative with dating profiles.

Amy takes a job at Sheldon's university, putting their relationship to the test. Howard ends up sleeping on Raj's couch after a fight with Bernadette.

Sheldon fears his major scientific breakthrough may haunt him for the rest of his career. Howard makes a grand romantic gesture to Bernadette.

Debby anxiously awaits news of Mido's arrival. Josh confronts Catie about her party girl ways, and Paula manifested her American fiancé, Thomas.

Dr. Lee treats Reginald, who has a rare growth on the back of his head. Che'Re has a prominent bump on her face, and Juan has painful boils on his neck.

When Molly gets angry with Mike for not listening to her vent about writing with Peggy, they go their separate ways for a day.

After Carl has a near-death experience while on duty, he tells Mike he's going to propose to Victoria. But can Mike keep a secret.

Dennis has several giant growths on his head. Juan has a rare condition he hopes Dr. Lee will understand. Natalie is covered in hundreds of mysterious dark bumps.

Pastor Juan's love of food made him overweight, but it was never a problem until he got too big to preach and sing to his congregation.

.. Bride Tara is shopping with Olympic figure skater and fashionista Johnny Weir. Meanwhile Taylor brings her fiancé Austin to help her find her dream gown.

New to wedding dress shopping, Farrah doesn't seem to know what she wants in a dress, whilst Stephanie's style is vintage glam and knows exactly what to go for.

Natalie's hoping Kleinfeld will be the last stop on her bridal gown tour of the North East, and Amy has lost 70 pounds but still sees herself as overweight.

Bride Monisha has come to Kleinfelds looking for a dress for her three wedding ceremonies, and Mary has a budget of thirty thousand dollars to buy two dresses.

Sheldon moves in with Dr. Sturgis for the weekend to experience college life. A lonely Mary tries to bond with the other Coopers during his absence.

Unhappy that school funds are going toward football rather than academics, Sheldon decides to run for class president.

Georgie is thrilled when Veronica stays at the Coopers' for a few days. Meanwhile, Meemaw and Dr. Sturgis celebrate their one-year anniversary.

The Coopers help a broken-hearted Pastor Jeff through a rough patch in his marriage. Meanwhile, Sheldon pressures church members for donations.

Sheldon invites the entire school to a party for the Nobel Prize announcements. Meanwhile, Meemaw learns more about Dr. Sturgis's past.

After Dr. Sturgis experiences a nervous breakdown, Mary worries Sheldon is headed down a similar path. Georgie finds he has a knack for sales.

Without Dr. Sturgis's university class, Sheldon takes his education into his own hands. Mary helps Pastor Jeff avoid temptation with his girlfriend.

Georgie and Mandy take matters into their own hands when Mary starts warming up to Fagenbacher. Also, Audrey struggles to cope with Connor's absence.

Sheldon's selfish demands force Leonard to reconsider their friendship. Meanwhile, Howard tries to pick his astronaut nickname.

When Sheldon is forced to take a vacation by the university, he goes to work with Amy in her neurobiology lab.

When a corner office at the university opens, Sheldon must compete for it with his office nemesis, Barry Kripke. Penny gets an unusual gift from Amy.

A change in Sheldon's routine forces him to re-evaluate his entire life, when his barber is sick. Howard rethinks his decision to go into space.

Sheldon chooses to participate in a guys-only weekend Star Wars gaming marathon rather than go with Amy to her aunt's birthday party.

It's a dream come true for Sheldon when he has a close encounter with his hero, Mr. Spock -legendary sci-fi icon Leonard Nimoy.

When Wolowitz gets to work with world-renowned scientist, Stephen Hawking, Sheldon is willing to do anything to meet his hero.

Howard's wedding plans are in jeopardy after the guys throw him a bachelor party, and details of his sexual history are leaked online.

When NASA reschedules Howard's mission and puts his wedding plans in jeopardy, he's forced to face his fears - and Bernadette's dad.

When Howard and Bernadette decide they want to be married before his NASA space launch, the gang rushes to put on a wedding.

Howard discovers that he can't escape his mother - even in space! Back on earth, meanwhile, Raj turns his existence as a third wheel into an art form.

After learning Penny is thinking about breaking up with Leonard, Sheldon tries to intervene. Howard is being picked on in space by the astronauts.

While the pressure of being in space starts to take its toll on Howard, Amy feels threatened when Sheldon hires a young female assistant, Alex.

When Howard returns from space, he doesn't get the hero's welcome he expected. Meanwhile, Game Night turns into a battle of the sexes.

The gang celebrates Halloween at Stuart's comic book store. Leonard and Penny discover a new spark in their relationship with a scientific seduction.

Sheldon's friendship with renowned scientist Stephen Hawking is threatened by a game of 'Words with Friends.

Bernadette pressures Howard to move out of his mother's house. Sheldon finds himself caught in the middle of a fight between Amy and Wil Wheaton.

Howard and Raj try to understand why Sheldon disappears every afternoon at 2:45. Leonard and Penny wrestle with jealousy in their relationship.

When the University reassigns Sheldon's unused parking spot to Howard, the ensuing turf battle affects the whole gang.

Sheldon plays nursemaid to a sick Amy, while Howard attempts to bond with his father-in-law on an upcoming fishing trip.

Jess is looking for love but has a giant bump on his neck. Former NFL defensive tackle, Marcell Dareus, hopes Dr. Lee can tackle his forehead lipoma.

Don has a case of crippling psoriasis that has completely taken over his body. Jeff has a huge growth over his spine that looks like a hunchback.