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The guys get Zack and Penny to join their Justice League costume for a New Year's Eve bash at the comic book store.

Their friendship becomes strained when Sheldon tries to take over Leonard's creation of a smartphone application that solves differential equations.

Howard is jealous when Bernadette runs into her old boyfriend at a science event they're attending.

Sheldon wants acting lessons from Penny, hoping they will make him a better teacher.

After meeting at a fundraising gala, an aged but wealthy Caltech donor makes Leonard ponder if he's willing to have sex with her to secure a donation.

Howard contemplates a serious decision in his relationship with Bernadette, and Leonard and Raj's sister start seeing each other again.

Sheldon is in a crisis when he realises he's not the epicentre of the group, so he decides to find new friends.

Leonard has a tough choice to make when Priya asks him to stop spending time with Penny, and Howard keeps pestering Sheldon with a magic trick.

The guys become sleuths to find out who hacked Sheldon's online-game account.

Sheldon and Amy decide to start rumours about themselves as a social test. Howard takes his relationship with Bernadette to an even higher level.

Dr. Lee meets Dee, a singer with a huge neck hump. Eli is embarrassed of his cheek bump but is worried that the removal could paralyse his face.

Firefighter Jimmy has numerous torso bumps that make it painful to play with his young son. Plus, Steven has a mystery bump on the back of his head.

Dr. Lee removes a painful bump from Christian's back, all while his stuffed animal companion watches. Plus, Soniya suffers from dark spots.

Jacqueline's shoulder growth makes it difficult to do fire spinning, her favourite hobby. And the mysterious bump on James' cheek loves to bleed.

After losing his long-time love, Joe wants the large bumps all over his head removed. The itchy, painful rash on Nisa's ears has spread to her face.

Cedric has a bump on his eye and a lump on his neck that stops him from working. Katherine's ear cluster puts her neighbourhood watch job at risk.

Despite a solid support network, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't help her.

Angelica searches for the perfect strapless gown, but her mum, who is paying for the dress, has other ideas. Will she have to compromise to please mum.

When Sheldon learns the house next door is for sale, he looks for the perfect neighbours. Missy pitches against her boyfriend at the baseball game.

Sheldon has a scientific breakthrough at the dentist. Dale and Meemaw go to the casino. Georgie makes a mistake when he's left in charge of the store.

Sheldon discovers that Mary's been keeping a secret about his future. Also, Meemaw is furious when she learns that Dale fired Georgie.

After graduating high school, Sheldon has a breakdown when he realises he may not be ready for college. Also, Dale tries to make amends with Meemaw.

While Sheldon volunteers at a local train museum, Missy embarks on a new stage of womanhood, and Georgie discovers his mother's guilty pleasure.

Sheldon is determined to ride his bike without training wheels and has Missy teach him. Mary and George argue over parenting styles.

Priya uses her legal expertise to rip apart Sheldon's roommate agreement, and the women take the flustered Sheldon out dancing.

Raj makes an attempt to cure his phobia of talking to women, and Penny spies on Leonard and Priya with the help of Bernadette.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Penny worries that she's screwed things up permanently with her friends after her night with Raj, while Sheldon takes command of the paintball team.

Leonard and Amy get to know each other better at a co-worker's wedding. Howard and Bernadette spend the weekend with Mrs. Wolowitz.

Raj is upset he's the only one of the four guys who's not in a relationship, so Penny sets out to find the perfect date.

Sheldon and Leonard get invited to a housewarming party at Wil Wheaton's house. Howard gets an out-of-this-world opportunity.

Craving a little motherly love, Sheldon competes with the gang for his mother's attention when she comes to visit.

A cute comic book artist tests Leonard's relationship with Priya, while Sheldon, getting into the Halloween spirit, tries to scare the guys.

Amy is heartbroken when Bernadette and Penny go shopping for wedding dresses without her.

Can friends with benefits still be friends without? Leonard and Penny try hanging out alone, while Sheldon must overcome his fear of birds.

Sheldon becomes jealous and considers taking his relationship with Amy to the next level when Stuart from the comic book store asks her out on a date.

Leonard must face his fears after being contacted by his high school tormentor, while Penny realises that she might have been a bully herself.

Sheldon gets in trouble with Amy, and it's up to Penny to teach him how to be a better boyfriend. Howard deals with Bernadette's dislike of children.

Everything might change when Leonard offers Penny a spur of the moment invitation to a romantic dinner for two on the 100th episode of the series.

Leonard and Penny experiment with dating again by 'beta testing' their relationship. Raj develops a weird bond with his phone's virtual assistant.

Sheldon's selfish demands force Leonard to reconsider their friendship. Meanwhile, Howard tries to pick his astronaut nickname.

When Sheldon is forced to take a vacation by the university, he goes to work with Amy in her neurobiology lab.

When a corner office at the university opens, Sheldon must compete for it with his office nemesis, Barry Kripke. Penny gets an unusual gift from Amy.

Jim feels ganged up on when Georgie and Audrey make changes to the tire store, and Mandy helps Georgie navigate a fight between her parents.

Mandy finds out Meemaw runs an illegal sportsbook and wants in on the action. Meanwhile, Georgie struggles to keep Mandy's new job a secret.

Ed Gamble hosts as captains Richard Ayoade, Joanne McNally and teams defend unacceptable views: Rhys James argues to ban retirement before 90.

Ed Gamble, Richard Ayoade and Joanne McNally welcome some brilliant guest comedians to share their wild, unwise or downright unacceptable opinions.