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The guys get Zack and Penny to join their Justice League costume for a New Year's Eve bash at the comic book store.

Their friendship becomes strained when Sheldon tries to take over Leonard's creation of a smartphone application that solves differential equations.

Howard is jealous when Bernadette runs into her old boyfriend at a science event they're attending.

Sheldon wants acting lessons from Penny, hoping they will make him a better teacher.

After meeting at a fundraising gala, an aged but wealthy Caltech donor makes Leonard ponder if he's willing to have sex with her to secure a donation.

Howard contemplates a serious decision in his relationship with Bernadette, and Leonard and Raj's sister start seeing each other again.

Graham has developed a huge, solid lump on his inner thigh which has given him life-threatening infections. Dr Emma is his only hope for treatment.

Dr. Emma helps Alan get rid of the protrusion at the top of his back. And will she find a treatment for Jane's smelly, sore skin and Danielle's red face.

Do Iguanas Get Pimples Too? Dr. Lee faces off with iguana-wrangler Madison's head growths. Chanel suffers from painful cyst tunnels that leak and smell like the food she eats.

Sue sells a huge amount of sausage and cheese samples for the school but must stand up for herself when the school fails to recognise her achievement.

Brick's teachers tell Frankie and Mike that Brick is socially challenged, so Mike thinks basketball is the answer to help Brick interact with others.

Mike is furious when Axl accidentally breaks the front door. Frankie must sell a car within a week or be forced to wear a dog suit outside the lot.

Bob suffers from mysterious open-wound sores all over his body. Virginia can't wait to have her lump removed. Tom is desperate to find a cure for his itchy skin.

Holly already has a failed weight loss surgery, so to succeed she must alter more than her eating habits. Can she overcome the childhood trauma which still haunts her.

Self-confessed Malibu Barbie, Yasmin, brings her dad wedding dress shopping, and daddy's girl Amy has a huge secret tattoo, but is ready to reveal it to her dad.

The sister of NBA star Stephen Curry hunts for her dream wedding dress. Plus, Cami Lee returns with her over-the-top mum in search of the perfect black dress.

Sue sells a huge amount of sausage and cheese samples for the school but must stand up for herself when the school fails to recognise her achievement.

Brick's teachers tell Frankie and Mike that Brick is socially challenged, so Mike thinks basketball is the answer to help Brick interact with others.

Mike is furious when Axl accidentally breaks the front door. Frankie must sell a car within a week or be forced to wear a dog suit outside the lot.

Sheldon and Georgie bond over a money-making opportunity. Meanwhile, Mary is concerned when Missy misuses religion.

Meemaw meets Dale's ex-wife, while Sheldon is forced to work on a group project with reluctant college students.

Sheldon visits CalTech for the first time. Meanwhile, Georgie is furious when Mary listens in on a phone call with his girlfriend.

Penny asks Leonard to lie to her visiting father, while Howard, Raj and Bernadette spend all night looking through a telescope.

Amy crushes on one of Penny's dim ex-boyfriends, Zack. Raj and Wolowitz argue over who'd be the better superhero.

The guys get Zack and Penny to join their Justice League costume for a New Year's Eve bash at the comic book store.

Their friendship becomes strained when Sheldon tries to take over Leonard's creation of a smartphone application that solves differential equations.

Howard is jealous when Bernadette runs into her old boyfriend at a science event they're attending.

Sheldon wants acting lessons from Penny, hoping they will make him a better teacher.

After meeting at a fundraising gala, an aged but wealthy Caltech donor makes Leonard ponder if he's willing to have sex with her to secure a donation.

Howard contemplates a serious decision in his relationship with Bernadette, and Leonard and Raj's sister start seeing each other again.

Frankie accidentally hits Brick with a beer bottle as she attempts to toss it into a bag, causing a small scratch that leads to big repercussions.

Frankie's dream of an idyllic family Thanksgiving is thwarted when Mr. Ehlert forces the staff to work on the holiday.

Frankie observes what she thinks are the perfect siblings and it becomes her mission to make her kids stop fighting and interact as a loving family.

Sheldon accuses Dr. Sturgis of plagiarism. Georgie has an awkward run-in with Veronica while on a date with his new girlfriend, Jana.

When George Sr. accidentally lands the school librarian in the hospital, the Cooper family look after her. Meemaw gives Georgie relationship advice.

When Sheldon learns the house next door is for sale, he looks for the perfect neighbours. Missy pitches against her boyfriend at the baseball game.

Sheldon is in a crisis when he realises he's not the epicentre of the group, so he decides to find new friends.

Leonard has a tough choice to make when Priya asks him to stop spending time with Penny, and Howard keeps pestering Sheldon with a magic trick.

The guys become sleuths to find out who hacked Sheldon's online-game account.

Sheldon and Amy decide to start rumours about themselves as a social test. Howard takes his relationship with Bernadette to an even higher level.

Priya uses her legal expertise to rip apart Sheldon's roommate agreement, and the women take the flustered Sheldon out dancing.

Raj makes an attempt to cure his phobia of talking to women, and Penny spies on Leonard and Priya with the help of Bernadette.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

There are only two foods that won't send Caroline into anaphylaxis. Touching almost anything causes Ariana's 'butterfly skin' to blister and tear.

Walk The Walk, Talk The Talk. New prosthetics may be housebound Zahra's ticket to freedom. Mahogany's leg weighs nearly 100 pounds due to lymphedema. Joseph was born without a jaw.

Ed Gamble hosts as comedians defend unacceptable opinions: Vittorio Angelone on a misunderstood Trump and Fatiha El-Ghorri backing arranged marriage.

Frankie accidentally hits Brick with a beer bottle as she attempts to toss it into a bag, causing a small scratch that leads to big repercussions.

Frankie's dream of an idyllic family Thanksgiving is thwarted when Mr. Ehlert forces the staff to work on the holiday.

Frankie observes what she thinks are the perfect siblings and it becomes her mission to make her kids stop fighting and interact as a loving family.

Steven's bump is so large, his daughter thinks he is growing a monster on his back. Ethan suffers from an irritating rash in an awkward place on his body.

Lacey has ballooned to over 600 lbs. She must now rally her divorced parents around her and find a way to modulate her moods that won't include binge-eating.

Team Ballgown Or Team Fishtail? It's fishtail vs ball gown when bride Amy comes to the shop with her entourage. Plus, blushing bride Alice wants beads and bling - can she find it.

Stephanie has a big budget and wants a show-stopper dress for her second marriage. Courtney Burson returns but has she finally made up her mind about a dress.

Frankie accidentally hits Brick with a beer bottle as she attempts to toss it into a bag, causing a small scratch that leads to big repercussions.

Frankie's dream of an idyllic family Thanksgiving is thwarted when Mr. Ehlert forces the staff to work on the holiday.

Frankie observes what she thinks are the perfect siblings and it becomes her mission to make her kids stop fighting and interact as a loving family.

Sheldon accuses Dr. Sturgis of plagiarism. Georgie has an awkward run-in with Veronica while on a date with his new girlfriend, Jana.

When George Sr. accidentally lands the school librarian in the hospital, the Cooper family look after her. Meemaw gives Georgie relationship advice.

When Sheldon learns the house next door is for sale, he looks for the perfect neighbours. Missy pitches against her boyfriend at the baseball game.

Sheldon is in a crisis when he realises he's not the epicentre of the group, so he decides to find new friends.

Leonard has a tough choice to make when Priya asks him to stop spending time with Penny, and Howard keeps pestering Sheldon with a magic trick.

The guys become sleuths to find out who hacked Sheldon's online-game account.

Sheldon and Amy decide to start rumours about themselves as a social test. Howard takes his relationship with Bernadette to an even higher level.

Priya uses her legal expertise to rip apart Sheldon's roommate agreement, and the women take the flustered Sheldon out dancing.

Raj makes an attempt to cure his phobia of talking to women, and Penny spies on Leonard and Priya with the help of Bernadette.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

While Frankie focuses on rehearsing for a solo in her church's Christmas mass, Mike takes over handling the chores of setting up the family Christmas.

Frankie and Mike must endure the unpredictability of teenagers when Sue wants a cool pair of jeans and Axl wants a car to impress a girl.

Frankie fears that a confrontation with trashy neighbour Rita Glossner is at hand when Sue has a run-in with her sons.

Sheldon has a scientific breakthrough at the dentist. Dale and Meemaw go to the casino. Georgie makes a mistake when he's left in charge of the store.

Sheldon discovers that Mary's been keeping a secret about his future. Also, Meemaw is furious when she learns that Dale fired Georgie.

After graduating high school, Sheldon has a breakdown when he realises he may not be ready for college. Also, Dale tries to make amends with Meemaw.

Penny worries that she's screwed things up permanently with her friends after her night with Raj, while Sheldon takes command of the paintball team.

Leonard and Amy get to know each other better at a co-worker's wedding. Howard and Bernadette spend the weekend with Mrs. Wolowitz.

Raj is upset he's the only one of the four guys who's not in a relationship, so Penny sets out to find the perfect date.

Sheldon and Leonard get invited to a housewarming party at Wil Wheaton's house. Howard gets an out-of-this-world opportunity.

Craving a little motherly love, Sheldon competes with the gang for his mother's attention when she comes to visit.

A cute comic book artist tests Leonard's relationship with Priya, while Sheldon, getting into the Halloween spirit, tries to scare the guys.

Amy is heartbroken when Bernadette and Penny go shopping for wedding dresses without her.

Can friends with benefits still be friends without? Leonard and Penny try hanging out alone, while Sheldon must overcome his fear of birds.

When Optimus Prime launches a mission to save Cybertron by destroying Earth, Bumblebee and Cade Yeager must lead the fight against their former ally.

Ed Gamble hosts as comedians defend unacceptable opinions: Vittorio Angelone on a misunderstood Trump and Fatiha El-Ghorri backing arranged marriage.

While Frankie focuses on rehearsing for a solo in her church's Christmas mass, Mike takes over handling the chores of setting up the family Christmas.

Frankie and Mike must endure the unpredictability of teenagers when Sue wants a cool pair of jeans and Axl wants a car to impress a girl.

Frankie fears that a confrontation with trashy neighbour Rita Glossner is at hand when Sue has a run-in with her sons.

John lost his sight at a young age and soon after began growing lumps on his body. Lynette has hundreds of pebble-sized bumps on her arms, chest, and belly.

Brandon is a talented musician and singer but his addiction to food has left him incapacitated, and he risks losing his girlfriend and his career dreams.

Jennifer takes her mum and opinionated sister wedding dress shopping, and picky princess Jordan won't accept anything less than 100% perfect.

While Frankie focuses on rehearsing for a solo in her church's Christmas mass, Mike takes over handling the chores of setting up the family Christmas.

Frankie and Mike must endure the unpredictability of teenagers when Sue wants a cool pair of jeans and Axl wants a car to impress a girl.

Frankie fears that a confrontation with trashy neighbour Rita Glossner is at hand when Sue has a run-in with her sons.

Sheldon has a scientific breakthrough at the dentist. Dale and Meemaw go to the casino. Georgie makes a mistake when he's left in charge of the store.

Sheldon discovers that Mary's been keeping a secret about his future. Also, Meemaw is furious when she learns that Dale fired Georgie.

After graduating high school, Sheldon has a breakdown when he realises he may not be ready for college. Also, Dale tries to make amends with Meemaw.

Penny worries that she's screwed things up permanently with her friends after her night with Raj, while Sheldon takes command of the paintball team.

Leonard and Amy get to know each other better at a co-worker's wedding. Howard and Bernadette spend the weekend with Mrs. Wolowitz.

Raj is upset he's the only one of the four guys who's not in a relationship, so Penny sets out to find the perfect date.

Sheldon and Leonard get invited to a housewarming party at Wil Wheaton's house. Howard gets an out-of-this-world opportunity.

Craving a little motherly love, Sheldon competes with the gang for his mother's attention when she comes to visit.

A cute comic book artist tests Leonard's relationship with Priya, while Sheldon, getting into the Halloween spirit, tries to scare the guys.

Amy is heartbroken when Bernadette and Penny go shopping for wedding dresses without her.

Can friends with benefits still be friends without? Leonard and Penny try hanging out alone, while Sheldon must overcome his fear of birds.

Mike's discovery of a dinosaur bone in the quarry causes the plant to get shut down for scientific research, forcing him to try and get a new job.

Frankie vows to stop yelling at and nagging her kids if they agree to follow-through on their schoolwork and chores without her intervention.

Valentine's Day unexpectedly finds Frankie and Mike home alone for a romantic evening. Unfortunately, the best-laid plans soon begin to unravel.

While Sheldon volunteers at a local train museum, Missy embarks on a new stage of womanhood, and Georgie discovers his mother's guilty pleasure.

Sheldon is determined to ride his bike without training wheels and has Missy teach him. Mary and George argue over parenting styles.

Bible Camp And A Chariot Of Love. Sheldon ends up in a fierce competition with Paige after their mums force them to attend Vacation Bible School. Georgie makes a questionable purchase.

Sheldon becomes jealous and considers taking his relationship with Amy to the next level when Stuart from the comic book store asks her out on a date.

Leonard must face his fears after being contacted by his high school tormentor, while Penny realises that she might have been a bully herself.

Sheldon gets in trouble with Amy, and it's up to Penny to teach him how to be a better boyfriend. Howard deals with Bernadette's dislike of children.

Everything might change when Leonard offers Penny a spur of the moment invitation to a romantic dinner for two on the 100th episode of the series.

Leonard and Penny experiment with dating again by 'beta testing' their relationship. Raj develops a weird bond with his phone's virtual assistant.

Sheldon's selfish demands force Leonard to reconsider their friendship. Meanwhile, Howard tries to pick his astronaut nickname.

When Sheldon is forced to take a vacation by the university, he goes to work with Amy in her neurobiology lab.

When a corner office at the university opens, Sheldon must compete for it with his office nemesis, Barry Kripke. Penny gets an unusual gift from Amy.

Mallorie offends Rasit over a prenup. Josh confronts Catie about her flirting. Anabelle is turned off by Shea's partying. Paula wants to make amends.

Aimee has a mohawk of cysts on her head. Plus, Edith's face markings and itchy skin condition turn out to be more than she expected.

Mike's discovery of a dinosaur bone in the quarry causes the plant to get shut down for scientific research, forcing him to try and get a new job.

Frankie vows to stop yelling at and nagging her kids if they agree to follow-through on their schoolwork and chores without her intervention.

Valentine's Day unexpectedly finds Frankie and Mike home alone for a romantic evening. Unfortunately, the best-laid plans soon begin to unravel.

Holy Cyst?! Kenny's rare condition causes hundreds of lumps to grow all over his body. Plus, Paula's painful and swollen feet ooze a foul-smelling substance.

Maja moves to Houston for a difficult weight-loss journey with the support of her boyfriend. But when he abruptly leaves her, she must do it alone.

Katie takes her mum's Princess Diana-style 80s wedding dress as inspiration, and Lauren plans a Twilight-themed wedding, but can she find a dress to fit the look.

Morticia Addams In A Good Way. Hayley Paige helps a bride wanting to look like a creepy fairy. Plus, a bride with a penchant for pickiness admits to already trying over 150 dresses.

George and Meemaw struggle to manage the Cooper household while Mary plans Pastor Jeff's wedding.

Sheldon catches a struggling Paige shoplifting. Meanwhile, George Sr. is furious when Georgie tries to buy his way out of chores.

George and Georgie go camping with Meemaw's new boyfriend, Dale, but things get complicated when her ex-boyfriend tags along.

Sheldon and Georgie bond over a money-making opportunity. Meanwhile, Mary is concerned when Missy misuses religion.

Meemaw meets Dale's ex-wife, while Sheldon is forced to work on a group project with reluctant college students.

Sheldon visits CalTech for the first time. Meanwhile, Georgie is furious when Mary listens in on a phone call with his girlfriend.

Sheldon accuses Dr. Sturgis of plagiarism. Georgie has an awkward run-in with Veronica while on a date with his new girlfriend, Jana.

When George Sr. accidentally lands the school librarian in the hospital, the Cooper family look after her. Meemaw gives Georgie relationship advice.

Howard uses a robotic arm for his own pleasure. Sheldon goes on a date with Amy Farrah Fowler, and Penny finds herself accompanying them.

Sheldon calculates that he'll be dead before technology exists to download his consciousness into a robot, so he goes on a healthy-living binge.

Sheldon breaks up with Amy Farrah Fowler, and the guys worry when he starts replacing her with cats.

Wolowitz is embarrassed when a secret of his is revealed, and Sheldon and Raj battle at work.

Sheldon meets Amy's mum and comes to the realisation he no longer wants to see Amy, and Leonard realises everyone is in a relationship except for him.

When Raj's sister has a one-day layover, he forbids the others from hooking up with her, unaware she and Leonard already did long ago.

The rest of the gang is interviewed by the FBI for Wolowitz's security clearance, with Sheldon accidentally letting slip some damaging information.

The guys camp out to see a print of Raiders of the Lost Ark with 21 extra seconds and are outraged to see Wil Wheaton and his friends skip the line.

Penny asks Leonard to lie to her visiting father, while Howard, Raj and Bernadette spend all night looking through a telescope.

Amy crushes on one of Penny's dim ex-boyfriends, Zack. Raj and Wolowitz argue over who'd be the better superhero.

The guys get Zack and Penny to join their Justice League costume for a New Year's Eve bash at the comic book store.

Their friendship becomes strained when Sheldon tries to take over Leonard's creation of a smartphone application that solves differential equations.

Howard is jealous when Bernadette runs into her old boyfriend at a science event they're attending.

Sheldon wants acting lessons from Penny, hoping they will make him a better teacher.

After meeting at a fundraising gala, an aged but wealthy Caltech donor makes Leonard ponder if he's willing to have sex with her to secure a donation.

Howard contemplates a serious decision in his relationship with Bernadette, and Leonard and Raj's sister start seeing each other again.

Sheldon is in a crisis when he realises he's not the epicentre of the group, so he decides to find new friends.

Leonard has a tough choice to make when Priya asks him to stop spending time with Penny, and Howard keeps pestering Sheldon with a magic trick.

The guys become sleuths to find out who hacked Sheldon's online-game account.

Sheldon and Amy decide to start rumours about themselves as a social test. Howard takes his relationship with Bernadette to an even higher level.

Dr. Lee meets Dee, a singer with a huge neck hump. Eli is embarrassed of his cheek bump but is worried that the removal could paralyse his face.

Firefighter Jimmy has numerous torso bumps that make it painful to play with his young son. Plus, Steven has a mystery bump on the back of his head.