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Howard contemplates a serious decision in his relationship with Bernadette, and Leonard and Raj's sister start seeing each other again.

Sheldon is in a crisis when he realises he's not the epicentre of the group, so he decides to find new friends.

Leonard has a tough choice to make when Priya asks him to stop spending time with Penny, and Howard keeps pestering Sheldon with a magic trick.

The guys become sleuths to find out who hacked Sheldon's online-game account.

Sheldon and Amy decide to start rumours about themselves as a social test. Howard takes his relationship with Bernadette to an even higher level.

Priya uses her legal expertise to rip apart Sheldon's roommate agreement, and the women take the flustered Sheldon out dancing.

Raj makes an attempt to cure his phobia of talking to women, and Penny spies on Leonard and Priya with the help of Bernadette.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Corey is a drag queen and has a bump dangling from his backside. And, the large growths on Virginia's upper arms make it difficult to travel in her RV.

Terry's nose growth has prevented him from meeting his grandkids. And, Remi has alligator-like skin and is not used to taking care of herself.

My Giant Nose Is Killing Me. Roger has huge growths on his nose that drip pus, attract flies and make breathing difficult. Plus, two sisters share many undiagnosed face bumps.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good. Justice has small lesions all over her body that get inflamed.

Debra has a large, brainlike growth on the side of her head that feels like a sponge, has crevices and emits an odour. Cowboy Dusten has painful lump on his knee.

At 700 pounds, 35-year-old Margaret is virtually bedbound. It's time for her to overcome her food addiction so she can finally live her life.

I Just Need To Find A Husband. Personal trainer Jessica needs a gown that shows off her muscular back, and Marie-Therese is shopping for a wedding dress despite still being single.

When Sheldon learns the house next door is for sale, he looks for the perfect neighbours. Missy pitches against her boyfriend at the baseball game.

Sheldon has a scientific breakthrough at the dentist. Dale and Meemaw go to the casino. Georgie makes a mistake when he's left in charge of the store.

Sheldon discovers that Mary's been keeping a secret about his future. Also, Meemaw is furious when she learns that Dale fired Georgie.

After graduating high school, Sheldon has a breakdown when he realises he may not be ready for college. Also, Dale tries to make amends with Meemaw.

While Sheldon volunteers at a local train museum, Missy embarks on a new stage of womanhood, and Georgie discovers his mother's guilty pleasure.

Sheldon is determined to ride his bike without training wheels and has Missy teach him. Mary and George argue over parenting styles.

Georgie's jealousy rears its head when Mandy gets sent on an overnight work trip with boss, who also happens to be her ex.

Audrey and Mary's feud rears its head when Georgie needs their help with the tyre store, and Jim's forced to confront his age after visiting the DMV.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Penny worries that she's screwed things up permanently with her friends after her night with Raj, while Sheldon takes command of the paintball team.

Leonard and Amy get to know each other better at a co-worker's wedding. Howard and Bernadette spend the weekend with Mrs. Wolowitz.

Raj is upset he's the only one of the four guys who's not in a relationship, so Penny sets out to find the perfect date.

Sheldon and Leonard get invited to a housewarming party at Wil Wheaton's house. Howard gets an out-of-this-world opportunity.

Craving a little motherly love, Sheldon competes with the gang for his mother's attention when she comes to visit.

A cute comic book artist tests Leonard's relationship with Priya, while Sheldon, getting into the Halloween spirit, tries to scare the guys.

Amy is heartbroken when Bernadette and Penny go shopping for wedding dresses without her.

Can friends with benefits still be friends without? Leonard and Penny try hanging out alone, while Sheldon must overcome his fear of birds.

Sheldon becomes jealous and considers taking his relationship with Amy to the next level when Stuart from the comic book store asks her out on a date.

Leonard must face his fears after being contacted by his high school tormentor, while Penny realises that she might have been a bully herself.

Sheldon gets in trouble with Amy, and it's up to Penny to teach him how to be a better boyfriend. Howard deals with Bernadette's dislike of children.

Everything might change when Leonard offers Penny a spur of the moment invitation to a romantic dinner for two on the 100th episode of the series.

Leonard and Penny experiment with dating again by 'beta testing' their relationship. Raj develops a weird bond with his phone's virtual assistant.

Sheldon's selfish demands force Leonard to reconsider their friendship. Meanwhile, Howard tries to pick his astronaut nickname.

When Sheldon is forced to take a vacation by the university, he goes to work with Amy in her neurobiology lab.

When a corner office at the university opens, Sheldon must compete for it with his office nemesis, Barry Kripke. Penny gets an unusual gift from Amy.

A change in Sheldon's routine forces him to re-evaluate his entire life, when his barber is sick. Howard rethinks his decision to go into space.

Sheldon chooses to participate in a guys-only weekend Star Wars gaming marathon rather than go with Amy to her aunt's birthday party.

It's a dream come true for Sheldon when he has a close encounter with his hero, Mr. Spock -legendary sci-fi icon Leonard Nimoy.

Dara Ó Briain introduces topical chat and hilarious games with two teams of top stand-up comedians as they look back over the week's news.

Ed Gamble hosts as captains Richard Ayoade, Joanne McNally and teams defend unacceptable views: Rhys James argues to ban retirement before 90.