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Mahfuza and Nelly are living with Harlequin ichthyosis, one of the world's rarest and most severe skin conditions.

A husband suffers a widow-maker heart attack, and a heating pad becomes a hurting pad. Small things like a headache or a broken nail can be lethal.

Frankie is arrested for Brick's late library book. Axl and Cassidy reunite during Spring Break but find themselves mostly kissing and not talking.

Sue gets multiple dates to the prom because she is too nice to turn down any of the boys who asked her. Brick asks Axl for help with a book report.

Mike reluctantly becomes coach of Sue's soccer team. After a hideous smell appears in the house, Frankie attempts to improve Brick's hygiene.

Margarita is a matriarch who has been hiding her armpit lump from her family. Bradley has a concerning growth that looks like raw meat on his leg.

Mike gained over 700lbs after his football dreams were dashed by multiple concussions. Now he must find a new purpose in life to avoid succumbing to pain and regret.

The Show That Lets It Go. Vicky is crushed when the dream dress she saw online is not what she hoped, so David comes to the rescue! Rachel wants a boho frock but will it suit her.

Back, Biceps, Booty. Victoria wants to show off her back, curves, and biceps, but Grandma wants her to cover up! Plus, Dominique has a little panic in the stockroom.

Frankie is arrested for Brick's late library book. Axl and Cassidy reunite during Spring Break but find themselves mostly kissing and not talking.

Sue gets multiple dates to the prom because she is too nice to turn down any of the boys who asked her. Brick asks Axl for help with a book report.

Mike reluctantly becomes coach of Sue's soccer team. After a hideous smell appears in the house, Frankie attempts to improve Brick's hygiene.

Sheldon accuses Dr. Sturgis of plagiarism. Georgie has an awkward run-in with Veronica while on a date with his new girlfriend, Jana.

When George Sr. accidentally lands the school librarian in the hospital, the Cooper family look after her. Meemaw gives Georgie relationship advice.

When Sheldon learns the house next door is for sale, he looks for the perfect neighbours. Missy pitches against her boyfriend at the baseball game.

Sheldon and Amy decide to start rumours about themselves as a social test. Howard takes his relationship with Bernadette to an even higher level.

Priya uses her legal expertise to rip apart Sheldon's roommate agreement, and the women take the flustered Sheldon out dancing.

Raj makes an attempt to cure his phobia of talking to women, and Penny spies on Leonard and Priya with the help of Bernadette.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Penny worries that she's screwed things up permanently with her friends after her night with Raj, while Sheldon takes command of the paintball team.

Leonard and Amy get to know each other better at a co-worker's wedding. Howard and Bernadette spend the weekend with Mrs. Wolowitz.

Raj is upset he's the only one of the four guys who's not in a relationship, so Penny sets out to find the perfect date.

Frankie pleads with an unyielding Rita Glossner to take down her irritating wind chimes.Sue informs the family that she and Darrin are dating again.

A stressed Sue frantically tries to earn a scholarship for college. Frankie covertly tries to make up for a forgotten task at work.

Needing a break, Frankie sets up office hours to deal with her kids demands. Brick invites his surprising new friends over for a book club meeting.

Sheldon has a scientific breakthrough at the dentist. Dale and Meemaw go to the casino. Georgie makes a mistake when he's left in charge of the store.

Sheldon discovers that Mary's been keeping a secret about his future. Also, Meemaw is furious when she learns that Dale fired Georgie.

After graduating high school, Sheldon has a breakdown when he realises he may not be ready for college. Also, Dale tries to make amends with Meemaw.

Sheldon and Leonard get invited to a housewarming party at Wil Wheaton's house. Howard gets an out-of-this-world opportunity.

Craving a little motherly love, Sheldon competes with the gang for his mother's attention when she comes to visit.

A cute comic book artist tests Leonard's relationship with Priya, while Sheldon, getting into the Halloween spirit, tries to scare the guys.

Amy is heartbroken when Bernadette and Penny go shopping for wedding dresses without her.

Can friends with benefits still be friends without? Leonard and Penny try hanging out alone, while Sheldon must overcome his fear of birds.

Sheldon becomes jealous and considers taking his relationship with Amy to the next level when Stuart from the comic book store asks her out on a date.

Leonard must face his fears after being contacted by his high school tormentor, while Penny realises that she might have been a bully herself.

Sheldon gets in trouble with Amy, and it's up to Penny to teach him how to be a better boyfriend. Howard deals with Bernadette's dislike of children.

Dara Ó Briain makes sense of world events - kind of - with guests Rhys James, Angela Barnes, Neil Delamere, Ed Byrne, Finlay Christie and Zoe Lyons.

She's an advice columnist writing about how to get a guy to dump her within 10 days. He's a Casanova convinced he can make any girl fall for him.

Frankie pleads with an unyielding Rita Glossner to take down her irritating wind chimes.Sue informs the family that she and Darrin are dating again.

A stressed Sue frantically tries to earn a scholarship for college. Frankie covertly tries to make up for a forgotten task at work.

Needing a break, Frankie sets up office hours to deal with her kids demands. Brick invites his surprising new friends over for a book club meeting.

Drag queen Tameru is covered in tiny clusters of cysts on his chest, arms and neck. He discovered his bumps over a decade ago and still doesn't know what they are.

James needs to control his love for food in order to survive, but a death in the family sends him retreating back to the comforts he knows.

Give The Man What He Wants. Amanda's back at Kleinfeld to find a second dress after her fiancé hated her first pick. Plus, Kindra and Jamel forget a key element of their wedding.

Frankie pleads with an unyielding Rita Glossner to take down her irritating wind chimes.Sue informs the family that she and Darrin are dating again.

A stressed Sue frantically tries to earn a scholarship for college. Frankie covertly tries to make up for a forgotten task at work.

Needing a break, Frankie sets up office hours to deal with her kids demands. Brick invites his surprising new friends over for a book club meeting.

Sheldon has a scientific breakthrough at the dentist. Dale and Meemaw go to the casino. Georgie makes a mistake when he's left in charge of the store.

Sheldon discovers that Mary's been keeping a secret about his future. Also, Meemaw is furious when she learns that Dale fired Georgie.

After graduating high school, Sheldon has a breakdown when he realises he may not be ready for college. Also, Dale tries to make amends with Meemaw.

Sheldon and Leonard get invited to a housewarming party at Wil Wheaton's house. Howard gets an out-of-this-world opportunity.

Craving a little motherly love, Sheldon competes with the gang for his mother's attention when she comes to visit.

A cute comic book artist tests Leonard's relationship with Priya, while Sheldon, getting into the Halloween spirit, tries to scare the guys.

Amy is heartbroken when Bernadette and Penny go shopping for wedding dresses without her.

Can friends with benefits still be friends without? Leonard and Penny try hanging out alone, while Sheldon must overcome his fear of birds.

Sheldon becomes jealous and considers taking his relationship with Amy to the next level when Stuart from the comic book store asks her out on a date.

Leonard must face his fears after being contacted by his high school tormentor, while Penny realises that she might have been a bully herself.

Sheldon gets in trouble with Amy, and it's up to Penny to teach him how to be a better boyfriend. Howard deals with Bernadette's dislike of children.

Sue tries to win a car while Mike and Rusty go on a road trip with Brick. Frankie must help Axl locate a missing desk or risk losing her $200 deposit.

The Hecks embark on a road trip to Disney World. Brick begs his parents to take a detour to North Carolina so he can meet his online girlfriend.

The Hecks arrive at Walt Disney World and try to stay positive when a series of misfortunes threaten to put a damper on their trip.

While Sheldon volunteers at a local train museum, Missy embarks on a new stage of womanhood, and Georgie discovers his mother's guilty pleasure.

Sheldon is determined to ride his bike without training wheels and has Missy teach him. Mary and George argue over parenting styles.

Bible Camp And A Chariot Of Love. Sheldon ends up in a fierce competition with Paige after their mums force them to attend Vacation Bible School. Georgie makes a questionable purchase.

Everything might change when Leonard offers Penny a spur of the moment invitation to a romantic dinner for two on the 100th episode of the series.

Leonard and Penny experiment with dating again by 'beta testing' their relationship. Raj develops a weird bond with his phone's virtual assistant.

Sheldon's selfish demands force Leonard to reconsider their friendship. Meanwhile, Howard tries to pick his astronaut nickname.

When Sheldon is forced to take a vacation by the university, he goes to work with Amy in her neurobiology lab.

When a corner office at the university opens, Sheldon must compete for it with his office nemesis, Barry Kripke. Penny gets an unusual gift from Amy.

A change in Sheldon's routine forces him to re-evaluate his entire life, when his barber is sick. Howard rethinks his decision to go into space.

Sheldon chooses to participate in a guys-only weekend Star Wars gaming marathon rather than go with Amy to her aunt's birthday party.

It's a dream come true for Sheldon when he has a close encounter with his hero, Mr. Spock -legendary sci-fi icon Leonard Nimoy.

Thomas and Paula clash before the wedding, Ashia ignores her friends' doubts, and Josh needs answers before walking down the aisle.

Jason lost confidence and motivation due to the large growth on his neck. Shawnell has multiple mystery bumps on her head that have destroyed her self-esteem.

Sue tries to win a car while Mike and Rusty go on a road trip with Brick. Frankie must help Axl locate a missing desk or risk losing her $200 deposit.

The Hecks embark on a road trip to Disney World. Brick begs his parents to take a detour to North Carolina so he can meet his online girlfriend.

The Hecks arrive at Walt Disney World and try to stay positive when a series of misfortunes threaten to put a damper on their trip.

Ear's In Trouble! Roger has a considerable growth on his shoulder that he calls his 'second head.' Jenna is a bubbly teenager with an even bigger bubble behind her ear.

Living on a homestead with his family, Lucas dreams of working in IT. But all he does is eat and game, and if he wants to lead a normal life, he needs Dr. Now's help.

Pink-mad Fiona wants a slender gown, but Mum prefers a princess style. Louise craves a grey wedding gown, but will mum think it's more dirty than dreamy.

Red doesn't want to settle for the dress she already bought. Randy gets a blast from the past, and one bride gets a taste of her own medicine.

George and Meemaw struggle to manage the Cooper household while Mary plans Pastor Jeff's wedding.

Sheldon catches a struggling Paige shoplifting. Meanwhile, George Sr. is furious when Georgie tries to buy his way out of chores.

George and Georgie go camping with Meemaw's new boyfriend, Dale, but things get complicated when her ex-boyfriend tags along.

Sheldon and Georgie bond over a money-making opportunity. Meanwhile, Mary is concerned when Missy misuses religion.

Meemaw meets Dale's ex-wife, while Sheldon is forced to work on a group project with reluctant college students.

Sheldon visits CalTech for the first time. Meanwhile, Georgie is furious when Mary listens in on a phone call with his girlfriend.

Sheldon accuses Dr. Sturgis of plagiarism. Georgie has an awkward run-in with Veronica while on a date with his new girlfriend, Jana.

When George Sr. accidentally lands the school librarian in the hospital, the Cooper family look after her. Meemaw gives Georgie relationship advice.

Wolowitz is embarrassed when a secret of his is revealed, and Sheldon and Raj battle at work.

Sheldon meets Amy's mum and comes to the realisation he no longer wants to see Amy, and Leonard realises everyone is in a relationship except for him.

When Raj's sister has a one-day layover, he forbids the others from hooking up with her, unaware she and Leonard already did long ago.

The rest of the gang is interviewed by the FBI for Wolowitz's security clearance, with Sheldon accidentally letting slip some damaging information.

The guys camp out to see a print of Raiders of the Lost Ark with 21 extra seconds and are outraged to see Wil Wheaton and his friends skip the line.

Penny asks Leonard to lie to her visiting father, while Howard, Raj and Bernadette spend all night looking through a telescope.

Amy crushes on one of Penny's dim ex-boyfriends, Zack. Raj and Wolowitz argue over who'd be the better superhero.

The guys get Zack and Penny to join their Justice League costume for a New Year's Eve bash at the comic book store.

Their friendship becomes strained when Sheldon tries to take over Leonard's creation of a smartphone application that solves differential equations.

Howard is jealous when Bernadette runs into her old boyfriend at a science event they're attending.

Sheldon wants acting lessons from Penny, hoping they will make him a better teacher.

After meeting at a fundraising gala, an aged but wealthy Caltech donor makes Leonard ponder if he's willing to have sex with her to secure a donation.

Howard contemplates a serious decision in his relationship with Bernadette, and Leonard and Raj's sister start seeing each other again.

Sheldon is in a crisis when he realises he's not the epicentre of the group, so he decides to find new friends.

Leonard has a tough choice to make when Priya asks him to stop spending time with Penny, and Howard keeps pestering Sheldon with a magic trick.

The guys become sleuths to find out who hacked Sheldon's online-game account.

Sheldon and Amy decide to start rumours about themselves as a social test. Howard takes his relationship with Bernadette to an even higher level.

Priya uses her legal expertise to rip apart Sheldon's roommate agreement, and the women take the flustered Sheldon out dancing.

Raj makes an attempt to cure his phobia of talking to women, and Penny spies on Leonard and Priya with the help of Bernadette.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Corey is a drag queen and has a bump dangling from his backside. And, the large growths on Virginia's upper arms make it difficult to travel in her RV.

Terry's nose growth has prevented him from meeting his grandkids. And, Remi has alligator-like skin and is not used to taking care of herself.

My Giant Nose Is Killing Me. Roger has huge growths on his nose that drip pus, attract flies and make breathing difficult. Plus, two sisters share many undiagnosed face bumps.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good. Justice has small lesions all over her body that get inflamed.

Debra has a large, brainlike growth on the side of her head that feels like a sponge, has crevices and emits an odour. Cowboy Dusten has painful lump on his knee.

At 700 pounds, 35-year-old Margaret is virtually bedbound. It's time for her to overcome her food addiction so she can finally live her life.

I Just Need To Find A Husband. Personal trainer Jessica needs a gown that shows off her muscular back, and Marie-Therese is shopping for a wedding dress despite still being single.

When Sheldon learns the house next door is for sale, he looks for the perfect neighbours. Missy pitches against her boyfriend at the baseball game.

Sheldon has a scientific breakthrough at the dentist. Dale and Meemaw go to the casino. Georgie makes a mistake when he's left in charge of the store.

Sheldon discovers that Mary's been keeping a secret about his future. Also, Meemaw is furious when she learns that Dale fired Georgie.

After graduating high school, Sheldon has a breakdown when he realises he may not be ready for college. Also, Dale tries to make amends with Meemaw.

While Sheldon volunteers at a local train museum, Missy embarks on a new stage of womanhood, and Georgie discovers his mother's guilty pleasure.

Sheldon is determined to ride his bike without training wheels and has Missy teach him. Mary and George argue over parenting styles.

Georgie's jealousy rears its head when Mandy gets sent on an overnight work trip with boss, who also happens to be her ex.

Audrey and Mary's feud rears its head when Georgie needs their help with the tyre store, and Jim's forced to confront his age after visiting the DMV.

Mrs. Wolowitz ends up in the hospital after Howard tells her he's marrying Bernadette. While there, Leonard stresses over Penny and Priya.

Penny worries that she's screwed things up permanently with her friends after her night with Raj, while Sheldon takes command of the paintball team.

Leonard and Amy get to know each other better at a co-worker's wedding. Howard and Bernadette spend the weekend with Mrs. Wolowitz.

Raj is upset he's the only one of the four guys who's not in a relationship, so Penny sets out to find the perfect date.

Sheldon and Leonard get invited to a housewarming party at Wil Wheaton's house. Howard gets an out-of-this-world opportunity.

Craving a little motherly love, Sheldon competes with the gang for his mother's attention when she comes to visit.

A cute comic book artist tests Leonard's relationship with Priya, while Sheldon, getting into the Halloween spirit, tries to scare the guys.

Amy is heartbroken when Bernadette and Penny go shopping for wedding dresses without her.

Can friends with benefits still be friends without? Leonard and Penny try hanging out alone, while Sheldon must overcome his fear of birds.

Sheldon becomes jealous and considers taking his relationship with Amy to the next level when Stuart from the comic book store asks her out on a date.

Leonard must face his fears after being contacted by his high school tormentor, while Penny realises that she might have been a bully herself.

Sheldon gets in trouble with Amy, and it's up to Penny to teach him how to be a better boyfriend. Howard deals with Bernadette's dislike of children.

Everything might change when Leonard offers Penny a spur of the moment invitation to a romantic dinner for two on the 100th episode of the series.

Leonard and Penny experiment with dating again by 'beta testing' their relationship. Raj develops a weird bond with his phone's virtual assistant.

Sheldon's selfish demands force Leonard to reconsider their friendship. Meanwhile, Howard tries to pick his astronaut nickname.

When Sheldon is forced to take a vacation by the university, he goes to work with Amy in her neurobiology lab.

When a corner office at the university opens, Sheldon must compete for it with his office nemesis, Barry Kripke. Penny gets an unusual gift from Amy.

A change in Sheldon's routine forces him to re-evaluate his entire life, when his barber is sick. Howard rethinks his decision to go into space.

Sheldon chooses to participate in a guys-only weekend Star Wars gaming marathon rather than go with Amy to her aunt's birthday party.

It's a dream come true for Sheldon when he has a close encounter with his hero, Mr. Spock -legendary sci-fi icon Leonard Nimoy.

Dara Ó Briain introduces topical chat and hilarious games with two teams of top stand-up comedians as they look back over the week's news.

Ed Gamble hosts as captains Richard Ayoade, Joanne McNally and teams defend unacceptable views: Rhys James argues to ban retirement before 90.

Dara Ó Briain introduces topical chat and hilarious games with two teams of top stand-up comedians as they look back over the week's news.

Bible Camp And A Chariot Of Love. Sheldon ends up in a fierce competition with Paige after their mums force them to attend Vacation Bible School. Georgie makes a questionable purchase.

Eric hopes Dr. Lee can remove the giant growth from his backside. Plus, Michael makes jokes, but he knows the bump on his head is anything but funny.

Robert has thousands of unique bumps on his arms that Dr. Lee has never seen. Stuart's cluster of back bumps disgusts his wife but thrills Dr. Lee.

Megan and Whitney hunt frocks for their Palm Springs ceremony. Sabrina seeks a gown for her Italian nuptials. Maryam's dress is blinged for her Vegas wedding.

At 700 pounds, Ontreon's faith in God kept him going, and he's training to become a minister. But if he can't believe in himself, he won't be able to stop eating.

Lori has kept a secret from her entourage and now it's time for the big reveal! Merchandise Director Dorothy tries on a wedding dress for the first time.

Sue tries to win a car while Mike and Rusty go on a road trip with Brick. Frankie must help Axl locate a missing desk or risk losing her $200 deposit.

The Hecks embark on a road trip to Disney World. Brick begs his parents to take a detour to North Carolina so he can meet his online girlfriend.

The Hecks arrive at Walt Disney World and try to stay positive when a series of misfortunes threaten to put a damper on their trip.

While Sheldon volunteers at a local train museum, Missy embarks on a new stage of womanhood, and Georgie discovers his mother's guilty pleasure.

Sheldon is determined to ride his bike without training wheels and has Missy teach him. Mary and George argue over parenting styles.

Bible Camp And A Chariot Of Love. Sheldon ends up in a fierce competition with Paige after their mums force them to attend Vacation Bible School. Georgie makes a questionable purchase.

Everything might change when Leonard offers Penny a spur of the moment invitation to a romantic dinner for two on the 100th episode of the series.

Leonard and Penny experiment with dating again by 'beta testing' their relationship. Raj develops a weird bond with his phone's virtual assistant.

Sheldon's selfish demands force Leonard to reconsider their friendship. Meanwhile, Howard tries to pick his astronaut nickname.

When Sheldon is forced to take a vacation by the university, he goes to work with Amy in her neurobiology lab.

When a corner office at the university opens, Sheldon must compete for it with his office nemesis, Barry Kripke. Penny gets an unusual gift from Amy.

A change in Sheldon's routine forces him to re-evaluate his entire life, when his barber is sick. Howard rethinks his decision to go into space.

Sheldon chooses to participate in a guys-only weekend Star Wars gaming marathon rather than go with Amy to her aunt's birthday party.

It's a dream come true for Sheldon when he has a close encounter with his hero, Mr. Spock -legendary sci-fi icon Leonard Nimoy.

Sue is ecstatic when she gets her braces removed. Axl beats Mike at basketball for the first time and Brick tries to find the perfect book bag.

Frankie and Mike scramble to afford sending Sue to a good college next year. Sue and Brad strive to do something different with the school play.

Sue finds herself becoming a bit twitchy and nervous when she begins to drink a lot of coffee. Axl panics when he needs to declare a college major.

While Mary and George take a trip, Georgie freaks out when his girlfriend thinks she's pregnant. Dale and Meemaw work out their relationship issues.

While college orientation does not go as Sheldon planned, Mary is mistaken for a university student and invited to a party.

Sheldon's first day of college is derailed by his new philosophy teacher. Mary and Brenda live vicariously through Missy's first day of middle school.

When Wolowitz gets to work with world-renowned scientist, Stephen Hawking, Sheldon is willing to do anything to meet his hero.

Howard's wedding plans are in jeopardy after the guys throw him a bachelor party, and details of his sexual history are leaked online.

When NASA reschedules Howard's mission and puts his wedding plans in jeopardy, he's forced to face his fears - and Bernadette's dad.

When Howard and Bernadette decide they want to be married before his NASA space launch, the gang rushes to put on a wedding.

Howard discovers that he can't escape his mother - even in space! Back on earth, meanwhile, Raj turns his existence as a third wheel into an art form.

After learning Penny is thinking about breaking up with Leonard, Sheldon tries to intervene. Howard is being picked on in space by the astronauts.

While the pressure of being in space starts to take its toll on Howard, Amy feels threatened when Sheldon hires a young female assistant, Alex.

When Howard returns from space, he doesn't get the hero's welcome he expected. Meanwhile, Game Night turns into a battle of the sexes.

Dara Ó Briain introduces topical chat and hilarious games with two teams of top stand-up comedians as they look back over the week's news.

A US Army colonel and a civilian woman supervising him must track down stolen Russian nuclear weapons before they're used by terrorists.