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Sheldon joins Dr. Linkletter and Dr. Sturgis on a science road trip, landing them in the middle of nowhere. Georgie continues to lie about his age.

When Meemaw's gambling room is a success, she ends up with a suitcase of illegal cash. Missy starts a business, and Sheldon tries the stock market.

Amy fibs about repairs being made to her apartment. Later, they present an episode of 'Fun with Flags' in Penny's apartment.

A successful gene experiment leaves Sheldon excited to procreate with Amy. Raj is reluctant to reveal what his new woman does for a living.

A coworker's MacArthur Genius fellowship award leaves Sheldon stone cold jealous. Howard finds a remote-control Stephen Hawking action figure.

A divide develops between Sheldon and Leonard when divvying up their shared belongings. Raj and Stuart battle to provide Bernadette the most help.

While Sheldon and Amy celebrate Amy's birthday, Howard and Bernadette welcome their new Baby Wolowitz.

Sheldon and Amy visit Leonard and Penny for the first time since the holidays and share details about their terrible trip to Texas.

After a disagreement, Penny takes off for a spa weekend, and Sheldon plays peacemaker. Howard and Raj battle a noisy floor in the baby's room.

Sheldon tests an MIT invention, Leonard has trouble when Penny announces her brother's visit, and Raj seeks advice from old girlfriends.

Rasit offends Mallorie's ex-fling Brandon, Edward learns Marissa's strict house rules and meets her ex, and Debby and Mido struggle to make amends.

Krystal is a witch who wants to clear a curse of a cyst from her face. Keven wants a butt lipoma removed to get his bum back into a regular shape.

Don has a case of crippling psoriasis that has completely taken over his body. Jeff has a huge growth over his spine that looks like a hunchback.

Ronen has a huge but mysterious lump above his knee. Meanwhile Amber is suffering from a debilitating skin disease no one understands.

Weighing 791-lbs, James is bedridden, unable to stand, and can barely move his legs. He may only have a few months to live. Can bypass surgery save his life.

Jess' mum was given a tough cancer diagnosis, so finding the right dress with her is important. But, they have very different ideas about the type of dress.

Jordan wants a blush dress and her bridesmaids to be in white, her mum wants her in a 'Big Fat Gypsy Wedding' style - what will she pick.

Sheldon faces consequences after installing a pirated computer game. Mary and Meemaw take Brenda out for Girls Night, and George watches Billy.

Sheldon is at odds with Paige once again when she considers enrolling at East Texas Tech. Mary seeks the advice of June when looking for a change.

The Coopers discuss the possibilities of black holes and alternate universes when Dr. Sturgis comes over for dinner.

Missy's first heartbreak triggers a series of events that lead the Cooper family to the brink.

Sheldon and Missy both run away from home, while Mary gets some upsetting news about her husband, George.

Sheldon encourages Missy to question the Bible. Meemaw determines to catch George Sr. in a lie, and Mary helps Pastor Jeff search for a youth pastor.

While Sheldon tries to convince Dr. Sturgis to return to the university, Georgie upsets the family when he makes a life-changing decision.

Pish Posh And A Secret Room. While Meemaw opens a secret gambling room, Sheldon, Missy and Georgie adapt to new living arrangements.

Leonard and Sheldon's mothers come to town to celebrate their sons getting an award, but the opinionated women engage in an altercation over religion.

Leonard and Penny are pressured to set a wedding date by Sheldon, whose relationship with Amy has taken an interesting turn.

Penny has a problem dealing with Leonard's confession about having kissed another woman, while Sheldon is confused about Amy calling a time out.

To ease Penny's mind, Leonard pays a visit to the woman he kissed during his expedition to the North Sea. Sheldon's breakup leads him to retaliate.

The guys surprise Leonard with a belated bachelor-party weekend in Mexico, but their plans hit a bump in the road when they get a flat tire.

Sheldon reverts to 2003 when he learns that Leonard and Penny are moving in together, while Howard and Raj form a band to play at the comic store.

When Barry Kripke gives the guys fencing lessons, he makes a point of letting Sheldon know he's interested in dating Amy.

A helium shortage leads Sheldon and Leonard to do business with a dealer in the black market to acquire some of the element for an experiment.

Sheldon's interview for a 'Star Trek' documentary focusing on Spock turns up a shocking revelation about his breakup with Amy.

When Leonard, Penny and Bernadette learn that Amy is going out on a dinner date, the trio set out to spy on her and the guy.

Sheldon and Amy spend Thanksgiving at the aquarium, Wolowitz volunteers at a soup kitchen, and Penny realises that Leonard knows a lot about her.

God only knows what song is constantly playing in Sheldon's head, but it reminds him of Amy and leads to a surprising revelation.

Professor Proton visits Sheldon in a dream and gives him Obi-Wan-like advice about whether to go see the new Star Wars film or spend time with Amy.

Penny entices Leonard to meet with a psychiatrist, Stuart moves out of the Wolowitz house, and Howard and Bernadette find themselves at a loss.

Dealing with an under-the-weather Sheldon is draining for Penny, Leonard and the gang so they decide to treat themselves to a Sheldon-less weekend.

Sheldon's Meemaw visits and there's friction between her and Amy, which intensifies after the elderly woman blurts out a secret about Sheldon.

Sheldon and Amy celebrate Valentine's Day, Leonard and Penny feel the pangs of aging, and Howard and Bernadette find a surprise in their hot tub.

The gang learns Bernadette is pregnant and celebrates with karaoke. Meanwhile, Howard freaks out, convinced he must make more money for the baby.

Sheldon and the gang celebrate his birthday and he's surprised by a special guest.

Howard reconsiders entering into a legal partnership with Leonard and Sheldon, and the women offer Raj dating advice.

Ed Gamble, Richard Ayoade and Joanne McNally defend outrageous opinions. They tackle relationships, the royals and vasectomies.

Jason isolates due to a giant neck growth. Marisa dreads spider veins after surgery and Kobe hums to stay calm as a huge bump near his eye is removed.

Firefighter and passionate cyclist Dave is concerned about a pilar cyst on his head that prevents him from wearing helmets.

Patrick's nose is covered by huge bumps and he can barely breathe. Matt has suffered from neurofibromatosis his entire life and is in incredible pain.

Melissa covered her huge lipoma with a sweatshirt for years. Tyler's fear of cancer stopped his head lumps being diagnosed and Tahj is covered in painful boils.

While Mary's away, George finds himself giving advice on Missy's love life. And Georgie has a solution for Meemaw's business woes.

While Missy asks some uncomfortable questions about sex in church, Meemaw and Georgie go into business together.

At 42 years old, Angel is staring death in the face. She is struggling to make a positive change and be an active part of her partner and son's lives.

Jess seeks a dress she saw online but it's no longer available. Natasha wants a strappy gown, but her mum thinks her tattoos will steal the show.

Once Upon A Time In The North. Jade dreams of a fairytale 'Beauty and the Beast'-themed wedding. And, Gok helps cancer survivor Raven find a gown and regain her confidence.

Sheldon takes his first engineering class with Professor Boucher. Meanwhile, Meemaw and Dale help take care of his ex-wife, June.

While Sheldon battles the mysterious Grand Chancellor of the university over science requirements, Mary makes a shocking discovery about Georgie.

While George Sr. plays handyman at Brenda Sparks' house, Sheldon gets the science yips and has to learn how not to think.

Sheldon gets a dorm room all to himself, which soon becomes the campus hotspot. Meanwhile, Meemaw gets an unwanted business partner.

Sheldon acts as Mary's spy when he's forced to spend the night at church for a youth lock-in. Meanwhile, Georgie gets attracted to an older woman.

Sheldon attends his first comic book convention, and Mary tries selling makeup.

Sheldon shocks Amy with a startling revelation after she buys him a laptop. Raj throws Leonard and Howard under the bus when they lie to their wives.

Sheldon shares a secret about Leonard when the two go on a weekend trip with Penny and Amy; Raj goes all out with pregnancy gifts.

During a group get-together, a minor argument between Sheldon and Leonard turns into a heated debate, leaving the rest of the gang to choose sides.

Sheldon stays with Bernadette while the rest of the gang attends an event where they run into Penny's former boyfriend and meet Raj's girlfriend.

Sheldon hires Stuart to spend the day with Amy. Meanwhile Leonard's mother visits, and Penny just can't seem to connect with her.

Leonard's recently divorced parents roll into town, as does Sheldon's holy-roller mother, and all hell breaks loose.

The gang deals with the awkward aftermath of an overnight liaison between Sheldon's mum and Leonard's dad. Penny's dysfunctional family is in town.

An Air Force bigwig approaches the guys about their revolutionary invention, and Bernadette is upset with Penny after she accidentally leaks a secret.

Howard and Leonard are putting in late nights at work, Raj and a pregnant Bernadette spend a day together, and Penny and Amy take in a faculty party.

Sheldon and Amy decide to move in together. Meanwhile, Howard and Bernadette become upset when Raj learns the gender of their baby before they do.

Sheldon accuses Amy of not following the bathroom schedule. Meanwhile, Howard and Bernadette's staycation is interrupted by hot tub interlopers.

Feeling his baby kick sends Howard on a baby-items buying binge with Raj, Sheldon and Amy host a brunch, and Penny is invited to a sci-fi convention.

Amy fibs about repairs being made to her apartment. Later, they present an episode of 'Fun with Flags' in Penny's apartment.

A successful gene experiment leaves Sheldon excited to procreate with Amy. Raj is reluctant to reveal what his new woman does for a living.

A coworker's MacArthur Genius fellowship award leaves Sheldon stone cold jealous. Howard finds a remote-control Stephen Hawking action figure.

A divide develops between Sheldon and Leonard when divvying up their shared belongings. Raj and Stuart battle to provide Bernadette the most help.

While Sheldon and Amy celebrate Amy's birthday, Howard and Bernadette welcome their new Baby Wolowitz.

Sheldon and Amy visit Leonard and Penny for the first time since the holidays and share details about their terrible trip to Texas.

After a disagreement, Penny takes off for a spa weekend, and Sheldon plays peacemaker. Howard and Raj battle a noisy floor in the baby's room.

Sheldon tests an MIT invention, Leonard has trouble when Penny announces her brother's visit, and Raj seeks advice from old girlfriends.

Mandy struggles to get Georgie's family to join him for his first Thanksgiving without his dad.

Georgie joins a church to sell tires to the congregation. Mandy worries there is more to the story than that.

Ed, Richard and Joanne back more wild ideas. Guz has to lay into his hometown Coventry, Maisie tackles AI, and Chris takes on an Olympic legend.

Ed Gamble, Richard Ayoade and Joanne McNally defend outrageous opinions. They tackle relationships, the royals and vasectomies.