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After young father Matthew Podolak dies from antifreeze poisoning, the manner of his death remains undetermined until his brother embarks on a quest for the truth.

After young father Matthew Podolak dies from antifreeze poisoning, the manner of his death remains undetermined until his brother embarks on a quest for the truth.

Josh Mankiewicz reports on the mysterious disappearance of a Colorado rancher, whose friends think something isn't right and spend years fighting for answers.

A former judge retires to Florida and becomes the center of a mystery when he vanishes; police must unravel the possible connection between his disappearance and a ghastly discovery found buried at an abandoned golf course.

A weekend getaway at a Reno resort becomes the center of a mystery when a respected college professor disappears; police learn that the answers may lie buried beneath desert sands hundreds of miles away.

When a popular librarian vanishes after a night of dancing in Kentucky's capital city, the investigation focuses on family secrets, but police must unravel a different kind of secret to get to the truth buried in one of the city's parks.

Police believe the discovery of a body in a Florida backyard ends the desperate search for a missing woman, but it only deepens the mystery.

A beloved Missouri couple is thought to be swept away in a record-breaking deadly storm, but when a closer look at the family farm points to foul play, law enforcement searches for clues long since washed away.

When a Michigan mother disappears on an afternoon walk, investigators pin all hope on their sole eyewitness: a 10-year-old boy who may have witnessed the unthinkable.

After a woman falls to her death while hiking with her husband in Rocky Mountain National Park, rangers question if her death was an accident.

It's Friday the 13th and something sinister is about to happen: a chilling double murder in an upscale home; the evidence seems to tell a clear story until investigators discover a marriage filled with secrets and a story that doesn't add up.

A quiet night is shattered when intruders terrorize a Florida couple and their young son, killing one of them; investigators question the initial story; a tip leads them to another family with dark secrets, and that's when bonds are tested.

Annie Kasprzak has a second chance at a happy life after being adopted by her case worker; then, the 15-year-old vanishes; her parents find a note in her room that reveals a secret Annie has been hiding.

Fire chief Keith Bryan is shot dead in his home, leaving police to wonder who would want to slay the local hero.

A quiet North Dakota college town is left in fear after student Mindy Morgenstern is found murdered in her off-campus apartment.

The investigation into the mysterious disappearance of a Canadian man sparks an international manhunt for an elusive killer with multiple false identities.

Beauty queen Nona Dirksmeyer plans a future with the boyfriend she adores, then she is brutally killed; the crime shakes her hometown and exposes someone with a secret past.

The investigation into the mysterious disappearance of a Canadian man sparks an international manhunt for an elusive killer with multiple false identities.

Federal agents descend on a tiny Ohio town after a beloved girl goes missing; fearing their cornfields harbor a terrible truth, theories abound and panic spikes in this serene community; it's a race against time as investigators close in on a killer.

A pleasant Michigan day takes a dark turn when a field hand digs up a human skull in a sprawling backyard; the discovery leaves a tight-knit community shaken to its core and questioning whether a killer has penetrated the safety of its town.

A man of extraordinary power and prestige lives a double life.

A man of extraordinary power and prestige lives a double life.

A daughter finds her father, a former FBI agent, murdered at his house; police dig into the man's past and begin to think the key to the mystery might be quite close to home.

When a successful Arizona businesswoman disappears on a holiday shopping trip, investigators hunt for a kidnapper; when the killer takes his secrets to the grave, however, the only chance of finding her is a psychic's mysterious vision.

A young couple sets out from a holiday visit but never makes it home as law enforcement search dangerous terrain fraught with derelict silver mines.

A spunky grandmother and former bail bondswoman is a no-show at work, leaving friends and family desperate for answers. As investigators focus on felons from her former career, they soon discover she may not be the only one missing.

When a California mother wakes to find the door wide open and her daughter missing, law enforcement travel the country to find her until they discover a dark plot that began at the teen's doorstep.

When a widower disappears from his Southern California home, investigators find themselves caught up in a federal investigation involving the infamous hunt for skyjacker D.B. Cooper.

When a promising forensics student is found mutilated on a lonely stretch of Utah highway, her sheriff's department colleagues will stop at nothing to deliver justice.

Texas detectives investigating the murder of 22-year-old Molly Matheson uncover a trail of sexual assault crimes; Josh Mankiewicz is still disturbed by what survivors connected to the case told him about their fight for justice.

When 17-year-old Alissa Turney disappears, it takes years before detectives treat her case as a homicide; Andrea Canning reexamines the mystery and the dark family secrets the investigation unearthed.

An 18-year-old college student is found stabbed to death in her bedroom; Blayne Alexander revisits this case where a TV show influences the investigation.

When the body of an Ohio woman is found in a wooded area near her home months after she went missing, investigators must determine if her death was a suicide or homicide; the case and trial left Dennis Murphy hungry to know more.

A 49-year-old man was shot and killed while walking his dog in front of his Texas home. Josh Mankiewicz looks back at a case with an unusual motive.

A former ballerina shoots her husband in what she alleges was an act of self-defense; the ensuing investigation and dramatic trial spark protests and receives national attention.

A 49-year-old man was shot and killed while walking his dog in front of his Texas home. Josh Mankiewicz looks back at a case with an unusual motive.