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Three trailblazing scientists take on cancer, changing peoples' lives right now. Can Prof Sarah Blagden's breakthrough vaccine stop lung cancer before it even starts.

In Swansea and Bridgend, the competition includes terrible table manners and tactless banter, chicken lettuce boats, kitchen chaos - and a final showdown at the dinner table.

Kirstie Allsopp and Phil Spencer help a couple on the outskirts of Leeds. Karl loves their home's idyllic location, but Paul finds it too isolated and wants to move.

Another chance to catch Friday's new episode, with Pam Ayres in Dictionary Corner. Colin Murray, Rachel Riley and Susie Dent host.

Carrie convinces Doug to join a support group, but he decides to sign up for a totally different one instead.

Doug's position as the office clown is threatened by a new colleague's impersonations.

Doug fakes a heart attack to cover up the fact that he's forgotten Carrie's friend's name.

Debra finally cooks a dish that Ray, Robert and Frank all enjoy, but Marie is not impressed with her efforts.

Ray and Debra plan to get more time to themselves by encouraging Marie and Frank to make new friends. But all does not go to plan.

Debra pleads with Ray to allow her some time to herself without the family. But Marie is suspicious of her daughter-in-law, and Ray ends up spying on her..

On the day when he's hosting a wine-tasting party, Frasier hires a contractor to remove a scratch from his floor, but he takes apart the whole apartment.

Frasier marches into Kate's office demanding a pay rise. So why do they end up playing tonsil hockey instead.

The Adventures of Bad Boy and Dirty Girl: It's the morning after, and Kate and Frasier are worried about the consequences of their fling.

The Last Time I Saw Maris: Niles decides to stand up to Maris. So she decides to divorce him.

While Mike makes deal after deal, Frank hits a roadblock with a straight-talking Wisconsin collector who won't budge on prices.

Channel 4's midday news summary.

From sprucing up the salóns to decking the hallways, chateau owners get Christmas-ready. In the Loire Valley, Ben and Billie create the tallest Christmas tree in all of France.

The team at Blenheim Palace in Oxfordshire create a breathtaking, Hans Christian Andersen-inspired winter wonderland complete with a mile-long light trail.

Colin Murray, Rachel Riley and Susie Dent host, with Harry Aikines-Aryeetey in Dictionary Corner, as contestants race the clock to pit their wits against vowels, consonants and numbers.

John and Debbie are dreaming of a two-bedroom home that could one day become their permanent residence on the Costa Cálida in Spain. Lucy Alexander shows them what their money can buy.

Kirstie Allsopp brings the cheer with a wealth of joyful Christmas creations, and gives Festive HQ a glow-up. But which of her crafty helpers' decorations will be the star of her display.

The new series continues, with the second heat week. Just hours before their first guests arrive, three new couples take the keys to the properties that they'll run as B&Bs.

Laura Hamilton helps Jan and her son Jordan find a holiday home near the thriving town of La Duquesa. Are any of Laura's options perfect enough for Jan to put in an offer.

Channel 4's flagship news programme. Including the weather.

A short film for Stand Up To Cancer. After a harrowing year of life-changing treatment for stomach cancer, Chloe awaits the most important call of her life: is she finally cancer-free.

A voyage behind the scenes of the status-symbol superyachts belonging to some of the world's wealthiest movers and shakers, from Monaco to the Netherlands.

A gripping tale of murder and memory during the Troubles in Northern Ireland, with Lola Petticrew. When Belfast erupts into violence Dolours swears not to get involved..

The series continues with Stranger Things, Strictly, Celebrity Scam Interceptors, Malice, Songs of Praise, CBeebies Bedtime Stories and Animals on Drugs.

The celebs spend time on the sofa with George Clarke's Amazing Spaces, Swamp People: Serpent Invasion, The Woman in Black and the general election.